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anti-ADAM12 antibody :: Rabbit anti-Human A Disintegrin And Metalloprotease 12 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2028685 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $90 +1 FREE 8GB USB
0.02 mg  /  $105 +1 FREE 8GB USB
0.05 mg  /  $135 +1 FREE 8GB USB
0.1 mg  /  $170 +1 FREE 8GB USB
0.2 mg  /  $235 +1 FREE 8GB USB
1 mg  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloprotease 12 (ADAM12), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to A Disintegrin And Metalloprotease 12 (ADAM12)

 Product Gene Name   

anti-ADAM12 antibody

[Similar Products]
 Matching Pairs    Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
Antigen: A Disintegrin And Metalloprotease 12 (MBS2029666)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
APC-CY7 Conjugated Antibody: A Disintegrin And Metalloprotease 12 (ADAM12) (MBS2082138)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
PE Conjugated Antibody: A Disintegrin And Metalloprotease 12 (ADAM12) (MBS2082139)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
APC-CY7 Conjugated Antibody: A Disintegrin And Metalloprotease 12 (ADAM12) (MBS2082140)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
Cy3 Conjugated Antibody: A Disintegrin And Metalloprotease 12 (ADAM12) (MBS2082141)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
FITC Conjugated Antibody: A Disintegrin And Metalloprotease 12 (ADAM12) (MBS2082142)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
HRP Conjugated Antibody: A Disintegrin And Metalloprotease 12 (ADAM12) (MBS2082143)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloprotease 12 (MBS2028685)
Biotin Conjugated Antibody: A Disintegrin And Metalloprotease 12 (ADAM12) (MBS2096727)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF023476 mRNA
 3D Structure    ModBase 3D Structure for O43184
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against ADAM12. It has beenselected for its ability to recognize ADAM12 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Antigen-specific Affinity Chromatography.
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant ADAM12 (Ser513~His767) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2082140
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-ADAM12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADAM12 antibody   

WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.

 Application Notes for anti-ADAM12 antibody    Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-ADAM12 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-ADAM12 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ADAM12 antibody    (Figure.DAB staining on IHC-P. Samples: Human Tissue)
anti-ADAM12 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADAM12. It may not necessarily be applicable to this product.
 NCBI GI #    572882491
 NCBI GeneID    8038
 NCBI Accession #    NP_001275903.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288974.1 [Other Products]
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 UniProt Primary Accession #    O43184 [Other Products]
 UniProt Secondary Accession #    O60470; Q5JRP0; Q5JRP1; Q6P9E3; Q6UWB0 [Other Products]
 UniProt Related Accession #    O43184 [Other Products]
 Molecular Weight    80,263 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 12 isoform 4 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 12
 NCBI Official Symbol    ADAM12 [Similar Products]
 NCBI Official Synonym Symbols   
MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 12
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 12
 UniProt Synonym Protein Names   
Meltrin-alpha
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM12 [Similar Products]
 UniProt Synonym Gene Names    MLTN; ADAM 12 [Similar Products]
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 NCBI Summary for ADAM12    This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
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 UniProt Comments for ADAM12    ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 10q26.2

Cellular Component: extracellular space; integral component of membrane; nucleoplasm; plasma membrane

Molecular Function: metal ion binding; metalloendopeptidase activity; metallopeptidase activity; SH3 domain binding

Biological Process: cell adhesion; extracellular matrix organization; myoblast fusion; proteolysis
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 Research Articles on ADAM12    1. A novel regulator, myoferlin, of ADAM12 is discovered in HeLa cells and this protein increases ADAM12 expression level, stability, and its enzymatic activity, leading to the reduction of its substrate, E-cadherin, which plays important roles in the regulation of cell adhesion and tumor metastasis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAM12 antibodyPathways associated with anti-ADAM12 antibody
 Reference Product  PubMed Publications
 ADAM17 antibody  >27 publications with ADAM12 and ADAM17
 ADAM10 antibody  >25 publications with ADAM12 and ADAM10
 EGF antibody  >25 publications with ADAM12 and EGF
 EGFR antibody  >13 publications with ADAM12 and EGFR
 DLL1 antibody  >2 publications with ADAM12 and DLL1
 IGFBP3 antibody  >2 publications with ADAM12 and IGFBP3
 ITGB1 antibody  >1 publications with ADAM12 and ITGB1
 SH3D19 antibody  >1 publications with ADAM12 and SH3D19
 PACSIN3 antibody  >1 publications with ADAM12 and PACSIN3
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By EGFR Pathway antibodies  Signaling By EGFR Pathway Diagram
 Signaling By EGFR In Cancer Pathway antibodies  Signaling By EGFR In Cancer Pathway Diagram
 Signaling By EGFRvIII In Cancer Pathway antibodies  Signaling By EGFRvIII In Cancer Pathway Diagram
 Signaling By Ligand-Responsive EGFR Variants In Cancer Pathway antibodies  Signaling By Ligand-Responsive EGFR Variants In Cancer Pathway Diagram
 Signaling By Overexpressed Wild-Type EGFR In Cancer Pathway antibodies  Signaling By Overexpressed Wild-Type EGFR In Cancer Pathway Diagram
 Syndecan-4-mediated Signaling Events Pathway antibodies  Syndecan-4-mediated Signaling Events Pathway Diagram
Diseases associated with anti-ADAM12 antibodyOrgans/Tissues associated with anti-ADAM12 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >24 publications with ADAM12 and Necrosis
 Breast Neoplasms Antibodies  >22 publications with ADAM12 and Breast Neoplasms
 Hypertension Antibodies  >13 publications with ADAM12 and Hypertension
 Fibrosis Antibodies  >12 publications with ADAM12 and Fibrosis
 Disease Models, Animal Antibodies  >9 publications with ADAM12 and Disease Models, Animal
 Lung Neoplasms Antibodies  >9 publications with ADAM12 and Lung Neoplasms
 Inflammation Antibodies  >9 publications with ADAM12 and Inflammation
 Cardiomegaly Antibodies  >7 publications with ADAM12 and Cardiomegaly
 Hypertrophy Antibodies  >7 publications with ADAM12 and Hypertrophy
 Carcinoma, Hepatocellular Antibodies  >4 publications with ADAM12 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >56 publications with ADAM12 and Muscle
 Placenta Antibodies  >29 publications with ADAM12 and Placenta
 Vascular Antibodies  >27 publications with ADAM12 and Vascular
 Bone Antibodies  >24 publications with ADAM12 and Bone
 Embryonic Tissue Antibodies  >22 publications with ADAM12 and Embryonic Tissue
 Brain Antibodies  >15 publications with ADAM12 and Brain
 Lung Antibodies  >14 publications with ADAM12 and Lung
 Heart Antibodies  >12 publications with ADAM12 and Heart
 Liver Antibodies  >12 publications with ADAM12 and Liver
 Connective Tissue Antibodies  >12 publications with ADAM12 and Connective Tissue
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