NP_031429.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 8 isoform 1
NCBI Official Synonym Full Names
a disintegrin and metallopeptidase domain 8
NCBI Official Synonym Symbols
MS2; CD156; ADAM 8; CD156a; E430039A18Rik [Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 8
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 8
UniProt Synonym Protein Names
Cell surface antigen MS2; Macrophage cysteine-rich glycoprotein; CD_antigen: CD156a
UniProt Synonym Gene Names
NCBI Summary for ADAM8
This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]
UniProt Comments for ADAM8
ADAM8: Possible involvement in extravasation of leukocytes.
Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 7|7 F4
Cellular Component: alpha9-beta1 integrin-ADAM8 complex; cell surface; cytoplasm; dense core granule membrane; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; podosome; specific granule
Molecular Function: calcium ion binding; cell adhesion molecule binding; hydrolase activity; integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding
Biological Process: angiogenesis; blood vessel endothelial cell migration; cell morphogenesis; cell-matrix adhesion; cellular response to hypoxia; inflammatory response; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; negative regulation of thymocyte aggregation; osteoclast fusion; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of cellular extravasation; positive regulation of eosinophil migration; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of inflammatory response; positive regulation of innate immune response; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of neutrophil extravasation; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase B signaling; positive regulation of T cell differentiation in thymus; positive regulation of T cell migration; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; proteolysis; regulation of cell-cell adhesion; regulation of osteoclast differentiation; tissue morphogenesis
Research Articles on ADAM8
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Products associated with anti-ADAM8 antibody
Pathways associated with anti-ADAM8 antibody
Diseases associated with anti-ADAM8 antibody
Organs/Tissues associated with anti-ADAM8 antibody
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