NP_001100.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,262 Da
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 8 isoform 1
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 8
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 8
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 8
UniProt Synonym Protein Names
Cell surface antigen MS2; CD_antigen: CD156a
UniProt Synonym Gene Names
NCBI Summary for ADAM8
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
UniProt Comments for ADAM8
ADAM8: Possible involvement in extravasation of leukocytes.
Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: alpha9-beta1 integrin-ADAM8 complex; cell surface; cytoplasm; dense core granule membrane; integral component of plasma membrane; plasma membrane; podosome; specific granule
Molecular Function: calcium ion binding; cell adhesion molecule binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding
Biological Process: angiogenesis; cell morphogenesis; cellular response to hypoxia; extracellular matrix disassembly; inflammatory response; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; neutrophil degranulation; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of eosinophil migration; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of innate immune response; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of neutrophil extravasation; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase B signaling; positive regulation of protein processing; positive regulation of protein secretion; positive regulation of T cell differentiation in thymus; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; proteolysis; regulation of cell-cell adhesion
Research Articles on ADAM8
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Products associated with anti-ADAM8 antibody
Pathways associated with anti-ADAM8 antibody
Diseases associated with anti-ADAM8 antibody
Organs/Tissues associated with anti-ADAM8 antibody
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