NP_112217.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
168,460 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 12
NCBI Official Synonym Symbols
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Synonym Gene Names
NCBI Summary for ADAMTS12
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS12
ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5p13.3-p13.2
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: metalloendopeptidase activity; protein binding; zinc ion binding
Biological Process: cell migration; cell-matrix adhesion; cellular response to BMP stimulus; cellular response to interleukin-1; cellular response to tumor necrosis factor; negative regulation of cellular response to hepatocyte growth factor stimulus; negative regulation of cellular response to vascular endothelial growth factor stimulus; negative regulation of chondrocyte differentiation; negative regulation of hepatocyte growth factor receptor signaling pathway; proteoglycan catabolic process; proteolysis involved in cellular protein catabolic process; regulation of endothelial tube morphogenesis; regulation of inflammatory response
Research Articles on ADAMTS12
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Products associated with anti-ADAMTS12 antibody
Pathways associated with anti-ADAMTS12 antibody
Diseases associated with anti-ADAMTS12 antibody
Organs/Tissues associated with anti-ADAMTS12 antibody
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