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anti-ADAMTS12 antibody :: Rabbit anti-Mouse A Disintegrin And Metalloproteinase With Thrombospondin 12 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2028647 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $195 +1 FREE 8GB USB
0.1 mg  /  $250 +1 FREE 8GB USB
0.2 mg  /  $380 +1 FREE 8GB USB
1 mg  /  $905 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12)

 Product Gene Name   

anti-ADAMTS12 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S-SPA YWIVGNWSKC STTCGLGAYW RSVECSSGVD ADCTTIQRPD PAKKCHLRPC AGWRVGNWSK CSRNCSGGFK IREVQCMDSL DHHRSLRPFH CQFLAGAPPP LSMSCNLEPC GEWQVEPWSQ CSRSCGGGVQ ERGVSCPGGL CDWTKRPATT VPCNRHLCCH WATGNWELCN TSCGGGSQKR TIHCIPSENS TTEDQDQCLC DHQVKPPEFQ TCNQQACR
 3D Structure    ModBase 3D Structure for Q811B3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    The antibody is a rabbit polyclonal antibody raised against ADAMTS12. It has beenselected for its ability to recognize ADAMTS12 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    ADAMTS12 (Ser1318-Arg1538)
 Organism Species    Mus musculus (Mouse)
 Conjugate    No Conjugate
 Immunogen    Recombinant ADAMTS12 (Ser1318-Arg1538) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2084434
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-ADAMTS12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADAMTS12 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-ADAMTS12 antibody    Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-ADAMTS12 antibody    (Western Blot; Sample: Mouse Placenta lysate; Primary Ab: 2ug/ml Rabbit Anti-Mouse ADAMTS12 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
anti-ADAMTS12 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ADAMTS12 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-ADAMTS12 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ADAMTS12 antibody    (Figure.DAB staining on IHC-P. Samples: Mouse Tissue)
anti-ADAMTS12 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ADAMTS12. It may not necessarily be applicable to this product.
 NCBI GI #    153945812
 NCBI GeneID    239337
 NCBI Accession #    NP_780710.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_175501.3 [Other Products]
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 UniProt Primary Accession #    Q811B3 [Other Products]
 UniProt Secondary Accession #    Q8BK92; Q8BKY1; E9QKD6 [Other Products]
 UniProt Related Accession #    Q811B3 [Other Products]
 Molecular Weight    18,843 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
 NCBI Official Synonym Full Names    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
 NCBI Official Symbol    Adamts12 [Similar Products]
 NCBI Official Synonym Symbols   
AI605170; ADAMTS-12
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 12
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 12
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    Adamts12 [Similar Products]
 UniProt Synonym Gene Names    ADAM-TS 12; ADAM-TS12; ADAMTS-12 [Similar Products]
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 NCBI Summary for ADAMTS12    This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]
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 UniProt Comments for ADAMTS12    ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15|15 A1

Cellular Component: extracellular matrix; extracellular region; proteinaceous extracellular matrix

Molecular Function: hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding

Biological Process: cell migration; cell-matrix adhesion; cellular response to BMP stimulus; cellular response to interleukin-1; cellular response to tumor necrosis factor; negative regulation of cellular response to hepatocyte growth factor stimulus; negative regulation of cellular response to vascular endothelial growth factor stimulus; negative regulation of chondrocyte differentiation; negative regulation of hepatocyte growth factor receptor signaling pathway; proteoglycan catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of endothelial tube morphogenesis; regulation of inflammatory response
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 Research Articles on ADAMTS12    1. ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAMTS12 antibodyDiseases associated with anti-ADAMTS12 antibody
 Reference Product  PubMed Publications
 Comp antibody  >6 publications with ADAMTS12 and Comp
 Furin antibody  >2 publications with ADAMTS12 and Furin
 Grn antibody  >1 publications with ADAMTS12 and Grn
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with ADAMTS12 and Disease Models, Animal
 Inflammation Antibodies  >4 publications with ADAMTS12 and Inflammation
 Necrosis Antibodies  >4 publications with ADAMTS12 and Necrosis
 Mental Disorders Antibodies  >2 publications with ADAMTS12 and Mental Disorders
 Atherosclerosis Antibodies  >1 publications with ADAMTS12 and Atherosclerosis
 Arteriosclerosis Antibodies  >1 publications with ADAMTS12 and Arteriosclerosis
 Brain Diseases Antibodies  >1 publications with ADAMTS12 and Brain Diseases
 Breast Neoplasms Antibodies  >1 publications with ADAMTS12 and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with ADAMTS12 and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with ADAMTS12 and Kidney Diseases
Organs/Tissues associated with anti-ADAMTS12 antibody
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >5 publications with ADAMTS12 and Connective Tissue
 Lung Antibodies  >3 publications with ADAMTS12 and Lung
 Ovary Antibodies  >1 publications with ADAMTS12 and Ovary
 Embryonic Tissue Antibodies  >1 publications with ADAMTS12 and Embryonic Tissue
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