NP_620687.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,507 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 16 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 16
NCBI Official Synonym Symbols
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 16
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 16
UniProt Synonym Gene Names
NCBI Summary for ADAMTS16
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]
UniProt Comments for ADAMTS16
ADAMTS16: 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5p15.32
Cellular Component: proteinaceous extracellular matrix
Molecular Function: metalloendopeptidase activity; zinc ion binding
Biological Process: branching involved in ureteric bud morphogenesis; proteolysis; regulation of systemic arterial blood pressure
Research Articles on ADAMTS16
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Diseases associated with anti-ADAMTS16 antibody
Organs/Tissues associated with anti-ADAMTS16 antibody
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