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| Product Name
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A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2), Polyclonal Antibody
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| Also Known As
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Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2)
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Immunogen Sequence
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The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S- VRHEWA LKKWSPCSKP CGGGSQFTKY GCRRRLDSKM VHRAFCSALA KPKAIRRACN PQECSQPVWV TGEWEPCTQS CGRTGMQVRS VRCIQPLHNN TTRSVHTKHC NDHRPESRRA CNRELCPGRW RAGSWSQCSV TCGNGTQERP
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| 3D Structure
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ModBase 3D Structure for Q8C9W3
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| Clonality
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Polyclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Mouse
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| Specificity
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The antibody is a rabbit polyclonal antibody raised against ADAMTS2. It has been selected for its ability to recognize ADAMTS2 in immunohistochemical staining andwestern blotting.
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| Purity/Purification
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Affinity Chromatography
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| Form/Format
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Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
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| Concentration
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200ug/ml (lot specific)
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| Immunogen
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Recombinant ADAMTS2 (Val855~Pro1030) expressed in E.coli.
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| Conjugated Antibody
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The APC conjugated antibody version of this item is also available as catalog #MBS2082103
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| Preparation and Storage
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Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
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| Other Notes
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Small volumes of anti-ADAMTS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Applications Tested/Suitable for anti-ADAMTS2 antibody
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Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
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| Application Notes for anti-ADAMTS2 antibody
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Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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| Western Blot (WB) of anti-ADAMTS2 antibody
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(Figure. Western Blot; Sample: Recombinant ADAMTS2, Mouse.)
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| Immunohistochemistry (IHC) of anti-ADAMTS2 antibody
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(Figure. DAB staining on IHC-P; Samples: Mouse Liver Tissue)
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| Immunohistochemistry (IHC) of anti-ADAMTS2 antibody
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(Figure. DAB staining on IHC-P; Samples: Mouse Uterus Tissue.)
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| Immunohistochemistry (IHC) of anti-ADAMTS2 antibody
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(Figure. DAB staining on IHC-P; Samples: Mouse Brain Tissue.)
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TOP
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| NCBI/Uniprot data below describe general gene information for ADAMTS2. It may not necessarily be applicable to this product. |
| NCBI GI #
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33563307
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| NCBI GeneID
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216725
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| NCBI Accession #
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NP_783574.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_175643.3
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[Other Products]
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| UniProt Primary Accession #
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Q8C9W3
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[Other Products]
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| UniProt Related Accession #
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Q8C9W3
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[Other Products]
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| Molecular Weight
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135,299 Da
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TOP
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| NCBI Official Full Name
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A disintegrin and metalloproteinase with thrombospondin motifs 2 preproprotein
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| NCBI Official Synonym Full Names
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a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
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| NCBI Official Symbol
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Adamts2
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[Similar Products]
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| NCBI Official Synonym Symbols
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pNPI; PCINP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAM-TS 2
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[Similar Products]
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| NCBI Protein Information
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A disintegrin and metalloproteinase with thrombospondin motifs 2
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| UniProt Protein Name
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A disintegrin and metalloproteinase with thrombospondin motifs 2
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| UniProt Synonym Protein Names
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Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI
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| Protein Family
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A disintegrin and metalloproteinase with thrombospondin motifs
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| UniProt Gene Name
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Adamts2
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[Similar Products]
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| UniProt Synonym Gene Names
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ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; pNPI
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[Similar Products]
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| NCBI Summary for ADAMTS2
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]
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| UniProt Comments for ADAMTS2
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ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.14; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11|11 B1.3
Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding
Biological Process: collagen catabolic process; collagen fibril organization; lung development; protein processing; proteolysis; skin development; spermatogenesis
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TOP
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| Research Articles on ADAMTS2
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1. ADAMTS2 plays a critical role in cardiac hypertrophy induced by pressure overload in mouse model.
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Diseases associated with anti-ADAMTS2 antibody | Organs/Tissues associated with anti-ADAMTS2 antibody |
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Antibody 
