NP_055087.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
184,095 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 7
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 7
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 7
UniProt Synonym Protein Names
COMPase
UniProt Synonym Gene Names
NCBI Summary for ADAMTS7
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
UniProt Comments for ADAMTS7
ADAMTS7: Metalloprotease that may play a role in the degradation of COMP.
Protein type: Cell surface; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q25.1
Cellular Component: endoplasmic reticulum lumen
Molecular Function: metalloendopeptidase activity; metallopeptidase activity; protein binding
Biological Process: negative regulation of chondrocyte differentiation; proteolysis involved in cellular protein catabolic process
Research Articles on ADAMTS7
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Products associated with anti-ADAMTS7 antibody
Diseases associated with anti-ADAMTS7 antibody
Organs/Tissues associated with anti-ADAMTS7 antibody
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