NP_005091.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
180,990 Da
NCBI Official Full Name
A-kinase anchor protein 12 isoform 1
NCBI Official Synonym Full Names
A-kinase anchoring protein 12
NCBI Protein Information
A-kinase anchor protein 12
UniProt Protein Name
A-kinase anchor protein 12
UniProt Synonym Protein Names
A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen
UniProt Synonym Gene Names
NCBI Summary for AKAP12
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for AKAP12
AKAP12: a scaffold protein that contains 3 conserved PKA binding motifs. Suppresses podosome formation, inhibits RhoA and Cdc42 activity, and inhibits v-Src-induced oncogenic growth in NIH3T3. May inhibit Src-induced oncogenesis by reestablishing actin-based non-invasive cytoskeletal architecture.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: cell cortex; cytoplasm; cytoskeleton; cytosol; focal adhesion; plasma membrane
Molecular Function: adenylate cyclase binding; protein binding; protein kinase A binding
Biological Process: G-protein coupled receptor signaling pathway; positive regulation of cAMP biosynthetic process; positive regulation of protein kinase A signaling; protein targeting; regulation of protein kinase C signaling
Research Articles on AKAP12
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Products associated with anti-AKAP12 antibody
Pathways associated with anti-AKAP12 antibody
Diseases associated with anti-AKAP12 antibody
Organs/Tissues associated with anti-AKAP12 antibody
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