P10398.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,904 Da
NCBI Official Full Name
Serine/threonine-protein kinase A-Raf
NCBI Official Synonym Full Names
A-Raf proto-oncogene, serine/threonine kinase
NCBI Protein Information
serine/threonine-protein kinase A-Raf
UniProt Protein Name
Serine/threonine-protein kinase A-Raf
UniProt Synonym Protein Names
Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks
UniProt Synonym Gene Names
UniProt Entry Name
ARAF_HUMAN
NCBI Summary for ARAF
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
UniProt Comments for ARAF
ARAF: a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.
Protein type: EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Oncoprotein; TKL group; RAF family
Chromosomal Location of Human Ortholog: Xp11.4-p11.2
Cellular Component: cytosol
Molecular Function: ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein activity
Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of apoptosis; nerve growth factor receptor signaling pathway; positive regulation of peptidyl-serine phosphorylation; protein modification process; Ras protein signal transduction; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Research Articles on ARAF
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Products associated with anti-ARAF antibody
Pathways associated with anti-ARAF antibody
Diseases associated with anti-ARAF antibody
Organs/Tissues associated with anti-ARAF antibody
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