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anti-A1 antibody :: Rabbit A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS840386
Testing Data
Unit / Price
0.03 mg  /  $150 +1 FREE 8GB USB
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A1, Polyclonal Antibody

 Also Known As   

A1 Antibody

 Product Synonym Names    Bfl-1
 Product Gene Name   

anti-A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601056
 3D Structure    ModBase 3D Structure for Q16548
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purified
 Form/Format    100 ug (0.2 mg/ml) protein A purified rabbit anti-A1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
 Concentration    0.2 mg/ml (lot specific)
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 Immunogen    Synthetic peptide surrounding amino acid 37 of human A1
 Handling    The antibody solution should be gently mixed before use.
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of anti-A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-A1 antibody

   Background: A1 (also designated Bfl-1) is a Bcl-2 family protein that dimerizes with both Bcl-2 and Bax, and has been identified as a hematopoietic-specific, early inducible gene. Althomugh A1 demonstrated properties similar to those of Bcl-2, its function may be more temporally regulated during myeloid differentiation and is dependent on additional growth stimuli to confer its life promoting properties. A1 is abundantly expressed in bone marrow and at low levels in other tissues. A1 expression has been correlated to stomach cancer.
 Applications Tested/Suitable for anti-A1 antibody   

Western Blot (WB)

 Application Notes for anti-A1 antibody    Western blotting (0.5-4 ug/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal conditions should be determined individually. The A1 antibody detects A1 (Bfl-1) of human, mouse, and rat origins.
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 Testing Data of anti-A1 antibody    anti-A1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for A1. It may not necessarily be applicable to this product.
 NCBI GI #    168480072
 NCBI GeneID    597
 NCBI Accession #    NP_001108207.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114735.1 [Other Products]
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 UniProt Primary Accession #    Q16548 [Other Products]
 UniProt Secondary Accession #    Q6FGZ4; Q6FH19; Q86W13; Q99524 [Other Products]
 UniProt Related Accession #    Q16548 [Other Products]
 Molecular Weight    18,746 Da
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 NCBI Official Full Name    bcl-2-related protein A1 isoform 2
 NCBI Official Synonym Full Names    BCL2-related protein A1
 NCBI Official Symbol    BCL2A1 [Similar Products]
 NCBI Official Synonym Symbols   
GRS; ACC1; ACC2; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5
[Similar Products]
 NCBI Protein Information    bcl-2-related protein A1
 UniProt Protein Name    Bcl-2-related protein A1
 UniProt Synonym Protein Names   
Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
 Protein Family    A1-specific pheromone
 UniProt Gene Name    BCL2A1 [Similar Products]
 UniProt Synonym Gene Names    BCL2L5; BFL1; GRS; HBPA1; Bcl2-L-5 [Similar Products]
 UniProt Entry Name    B2LA1_HUMAN
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 NCBI Summary for A1    This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for A1    BCL2A1: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Interacts directly with BAK1, BID, BMF and BBC3. Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors. Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: mitochondrial outer membrane

Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of apoptosis
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 Research Articles on A1    1. Bcl2a1 overexpressing granulocytic MDSCs demonstrated prolonged survival.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-A1 antibodyPathways associated with anti-A1 antibody
 Reference Product  PubMed Publications
 JUN antibody  >16 publications with A1 and JUN
 RELA antibody  >4 publications with A1 and RELA
 NFKB1 antibody  >4 publications with A1 and NFKB1
 BBC3 antibody  >2 publications with A1 and BBC3
 BAK1 antibody  >2 publications with A1 and BAK1
 BIK antibody  >1 publications with A1 and BIK
 JUNB antibody  >1 publications with A1 and JUNB
 TP53 antibody  >1 publications with A1 and TP53
 Products by Pathway  Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-A1 antibodyOrgans/Tissues associated with anti-A1 antibody
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >22 publications with A1 and Leukemia
 Inflammation Antibodies  >10 publications with A1 and Inflammation
 Necrosis Antibodies  >10 publications with A1 and Necrosis
 Carcinoma Antibodies  >8 publications with A1 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >5 publications with A1 and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >4 publications with A1 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >3 publications with A1 and Neoplasms, Experimental
 Heart Diseases Antibodies  >3 publications with A1 and Heart Diseases
 Liver Diseases Antibodies  >3 publications with A1 and Liver Diseases
 Breast Neoplasms Antibodies  >3 publications with A1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with A1 and Blood
 Lymph Node Antibodies  >6 publications with A1 and Lymph Node
 Skin Antibodies  >5 publications with A1 and Skin
 Liver Antibodies  >4 publications with A1 and Liver
 Kidney Antibodies  >4 publications with A1 and Kidney
 Heart Antibodies  >4 publications with A1 and Heart
 Prostate Antibodies  >3 publications with A1 and Prostate
 Bone Marrow Antibodies  >2 publications with A1 and Bone Marrow
 Connective Tissue Antibodies  >2 publications with A1 and Connective Tissue
 Intestine Antibodies  >1 publications with A1 and Intestine
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