View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-A2M antibody :: Rabbit anti-Human A2M Polyclonal Antibody Catalog # MBS9415579 Unit / Price 0.1 mL / $315 +1 FREE 8GB USB 5x0.1 mL / $1,255 +1 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name A2M, Polyclonal Antibody Full Product Name A2M Antibody Product Synonym Names A2MD; CPAMD5; FWP007; S863-7 Product Gene Name anti-A2M antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM 103950 3D Structure ModBase 3D Structure for P01023 Clonality Polyclonal Host Rabbit Species Reactivity Human Specificity The antibody detects endogenous levels of total A2M protein. Purity/Purification Antigen Affinity Purification Form/Format Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Concentration 1.4 mg/ml (lot specific) Immunogen Synthetic peptide of human A2M Immunogen Type Peptide Preparation and Storage Store at -20 degree C Other Notes Small volumes of anti-A2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-A2M antibody Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. Product Categories/Family for anti-A2M antibody Total protein Ab Applications Tested/Suitable for anti-A2M antibody Immunohistochemistry (IHC) Application Notes for anti-A2M antibody Immunohistochemistry: 1:25-1:100 Immunohistochemistry (IHC) of anti-A2M antibody Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/20. Immunohistochemistry (IHC) of anti-A2M antibody Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/20. TOP NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product. NCBI GI # 66932947 NCBI GeneID 2 NCBI Accession # NP_000005.2 [Other Products] NCBI GenBank Nucleotide # NM_000014.4 [Other Products] UniProt Primary Accession # P01023 [Other Products] UniProt Secondary Accession # Q13677; Q59F47; Q5QTS0; Q68DN2; Q6PIY3; Q6PN97[Other Products] UniProt Related Accession # P01023[Other Products] Molecular Weight 163,291 Da TOP NCBI Official Full Name alpha-2-macroglobulin NCBI Official Synonym Full Names alpha-2-macroglobulin NCBI Official Symbol A2M [Similar Products] NCBI Official Synonym Symbols A2MD; CPAMD5; FWP007; S863-7 [Similar Products] NCBI Protein Information alpha-2-macroglobulin UniProt Protein Name Alpha-2-macroglobulin UniProt Synonym Protein Names C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 Protein Family Alpha-2-macroglobulin UniProt Gene Name A2M [Similar Products] UniProt Synonym Gene Names CPAMD5; Alpha-2-M [Similar Products] UniProt Entry Name A2MG_HUMAN TOP TOP UniProt Comments for A2M Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-A2M antibody Reference Product PubMed Publications APP antibody >18 publications with A2M and APP ALB antibody >6 publications with A2M and ALB APOA1 antibody >4 publications with A2M and APOA1 TGFB1 antibody >3 publications with A2M and TGFB1 SERPINF2 antibody >2 publications with A2M and SERPINF2 PLG antibody >2 publications with A2M and PLG SERPINA1 antibody >2 publications with A2M and SERPINA1 KLK3 antibody >1 publications with A2M and KLK3 Pathways associated with anti-A2M antibody Products by Pathway Pathway Diagram Complement And Coagulation Cascades Pathway antibodies Complement And Coagulation Cascades Pathway Diagram Complement And Coagulation Cascades Pathway antibodies Complement And Coagulation Cascades Pathway Diagram Complement And Coagulation Cascades Pathway antibodies Complement And Coagulation Cascades Pathway Diagram Degradation Of The Extracellular Matrix Pathway antibodies Degradation Of The Extracellular Matrix Pathway Diagram Extracellular Matrix Organization Pathway antibodies Extracellular Matrix Organization Pathway Diagram Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram HDL-mediated Lipid Transport Pathway antibodies HDL-mediated Lipid Transport Pathway Diagram Hemostasis Pathway antibodies Hemostasis Pathway Diagram IL6-mediated Signaling Events Pathway antibodies IL6-mediated Signaling Events Pathway Diagram Intrinsic Pathway Of Fibrin Clot Formation antibodies Intrinsic Pathway Of Fibrin Clot Formation Diagram Diseases associated with anti-A2M antibody Disease Name Pubmed Publications Nervous System Diseases Antibodies >99 publications with A2M and Nervous System Diseases Mental Disorders Antibodies >86 publications with A2M and Mental Disorders Alzheimer Disease Antibodies >83 publications with A2M and Alzheimer Disease Inflammation Antibodies >34 publications with A2M and Inflammation Liver Diseases Antibodies >16 publications with A2M and Liver Diseases Necrosis Antibodies >14 publications with A2M and Necrosis Lung Diseases Antibodies >14 publications with A2M and Lung Diseases Fibrosis Antibodies >13 publications with A2M and Fibrosis Disease Models, Animal Antibodies >11 publications with A2M and Disease Models, Animal Liver Cirrhosis Antibodies >8 publications with A2M and Liver Cirrhosis Organs/Tissues associated with anti-A2M antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >141 publications with A2M and Blood Liver Antibodies >43 publications with A2M and Liver Brain Antibodies >35 publications with A2M and Brain Vascular Antibodies >20 publications with A2M and Vascular Lung Antibodies >14 publications with A2M and Lung Prostate Antibodies >11 publications with A2M and Prostate Heart Antibodies >10 publications with A2M and Heart Bone Antibodies >8 publications with A2M and Bone Ovary Antibodies >7 publications with A2M and Ovary Intestine Antibodies >6 publications with A2M and Intestine TOP © 2006-24 MyBioSource.com. 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