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anti-AADAT antibody :: Goat AADAT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421820
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AADAT, Polyclonal Antibody

 Also Known As   

Goat anti-AADAT Antibody

 Product Synonym Names    Goat Anti-AADAT (int. ) Antibody; AADAT; aminoadipate aminotransferase; KAT2; KATII; L kynurenine/alpha aminoadipate aminotransferase; L-kynurenine/alpha-aminoadipate aminotransferase; alpha-aminoadipate aminotransferase; kynurenine aminotransferase II; AADAT antibody; aminoadipate aminotransferase antibody; KAT2 antibody; KATII antibody; L kynurenine/alpha aminoadipate aminotransferase antibody; L-kynurenine/alpha-aminoadipate aminotransferase antibody; alpha-aminoadipate aminotransferase antibody; kynurenine aminotransferase II antibody
 Product Gene Name   

anti-AADAT antibody

[Similar Products]
 Antibody/Peptide Pairs    AADAT peptide (MBS426425) is used for blocking the activity of AADAT antibody (MBS421820)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KPEDAKNPQK NTPK
 OMIM    611754
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-KPEDAKNPQKNTPK, from the internal region of the protein sequence according to NP_057312.1; NP_872603.1.
 Epitope    Internal region
 Note    Both reported variants represent identical protein (NP_057312.1and NP_872603.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-AADAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AADAT antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-AADAT antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 45kDa band observed in Human Liver lysates (calculated MW of 47.4kDa according to NP_057312.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-AADAT antibody    (1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-AADAT antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for AADAT. It may not necessarily be applicable to this product.
 NCBI GI #    7705897
 NCBI GeneID    51166
 NCBI Accession #    NP_057312.1 [Other Products]
 NCBI Related Accession #    NP_872603.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016228.3 [Other Products]
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 UniProt Secondary Accession #    Q9UL02; B3KP84 [Other Products]
 UniProt Related Accession #    Q8N5Z0 [Other Products]
 Molecular Weight    47,822 Da
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 NCBI Official Full Name    kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b
 NCBI Official Synonym Full Names    aminoadipate aminotransferase
 NCBI Official Symbol    AADAT [Similar Products]
 NCBI Official Synonym Symbols   
KAT2; KATII; KYAT2
[Similar Products]
 NCBI Protein Information    kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
 UniProt Protein Name    Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
 UniProt Synonym Protein Names   
2-aminoadipate aminotransferase; 2-aminoadipate transaminase (EC:2.6.1.39); Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2 (EC:2.6.1.7); Kynurenine--oxoglutarate transaminase II
 Protein Family    Kynurenine/alpha-aminoadipate aminotransferase
 UniProt Gene Name    AADAT [Similar Products]
 UniProt Synonym Gene Names    KAT2; KAT/AadAT; AadAT [Similar Products]
 UniProt Entry Name    AADAT_HUMAN
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 NCBI Summary for AADAT    This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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 UniProt Comments for AADAT    AADAT: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.6.1.39; Amino Acid Metabolism - tryptophan; EC 2.6.1.7; Transferase; Mitochondrial; Amino Acid Metabolism - lysine biosynthesis

Chromosomal Location of Human Ortholog: 4q33

Cellular Component: mitochondrial matrix

Molecular Function: 2-aminoadipate transaminase activity; kynurenine-oxoglutarate transaminase activity; protein homodimerization activity; pyridoxal phosphate binding

Biological Process: 2-oxoglutarate metabolic process; biosynthetic process; glutamate metabolic process; L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process; tryptophan catabolic process; tryptophan catabolic process to kynurenine
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 Research Articles on AADAT    1. Participants with major depression had lower levels of kynurenine compared to controls, with intermediate concentrations in somatoform patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-AADAT antibodyDiseases associated with anti-AADAT antibody
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway antibodies  Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway Diagram
 Lysine Biosynthesis Pathway antibodies  Lysine Biosynthesis Pathway Diagram
 Lysine Biosynthesis Pathway antibodies  Lysine Biosynthesis Pathway Diagram
 Lysine Catabolism Pathway antibodies  Lysine Catabolism Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with AADAT and Inflammation
 Immune System Diseases Antibodies  >1 publications with AADAT and Immune System Diseases
 Brain Diseases Antibodies  >1 publications with AADAT and Brain Diseases
 Necrosis Antibodies  >1 publications with AADAT and Necrosis
Organs/Tissues associated with anti-AADAT antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >6 publications with AADAT and Kidney
 Liver Antibodies  >4 publications with AADAT and Liver
 Brain Antibodies  >3 publications with AADAT and Brain
 Bone Antibodies  >1 publications with AADAT and Bone
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