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anti-ABAD antibody :: Rabbit ABAD Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9213364
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABAD, Polyclonal Antibody

 Also Known As   

ABAD Antibody (C-term)

 Product Synonym Names    hydroxyacyl-Coenzyme A dehydrogenase; type II isoform 1; 3-hydroxyacyl-CoA dehydrogenase type II; Type II HADH; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; Endoplasmic reticulum-associated amyloid beta-peptide binding protein; Short-chain type dehydrogenase/reductase XH98G2 ; ERAB; HSD17B10; SCHAD; HADH2 protein
 Product Gene Name   

anti-ABAD antibody

[Similar Products]
 Antibody/Peptide Pairs    ABAD peptide (MBS9226042) is used for blocking the activity of ABAD antibody (MBS9213364)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    199-235
 OMIM    300220
 3D Structure    ModBase 3D Structure for Q6IBS9
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: Bovine, Rat)
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 Specificity    This ABAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-235 amino acids from the C-terminal region of human ABAD.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ABAD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ABAD antibody

   Amyloid b-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases; unique among this family, it binds amyloid b-peptide and exhibits enzymatic activity toward a wide variety of substrates including linear alcohols. In an amyloid beta-abundant environment, ABAD appears to trigger cell stress induced by the amyloid peptide.
 Applications Tested/Suitable for anti-ABAD antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-ABAD antibody    WB~~1:1000
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 Western Blot (WB) of anti-ABAD antibody    Western blot analysis of anti-ABAD Pab in mouse kidney tissue lysate.ABAD(arrow) was detected using the purified Pab.
anti-ABAD antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ABAD antibody    Immunohistochemistry on Formalin-fixed and paraffin-embedded human prostate tissue. (Top)Coloration with the Anti-ABAD antibody at a 1:20 concentration. (Bottom)Antibody adsorbed to the antigen (peptide), negative control.Disappearance of cytoplasmic staining indicating the antibody is specific. Data and protocol courtesy of Marie-Hélène Levesque, Centre de Recherche du CHUL, Canada.
anti-ABAD antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ABAD antibody    ABAD Antibody (C214) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ABAD antibody detected the ABAD protein (arrow).
anti-ABAD antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ABAD. It may not necessarily be applicable to this product.
 NCBI GI #    83715985
 NCBI GeneID    3028
 NCBI Accession #    NP_001032900.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001037811.2 [Other Products]
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 UniProt Primary Accession #    Q6IBS9 [Other Products]
 UniProt Secondary Accession #    Q5H927; Q6IBS9; Q8TCV9; Q96HD5 [Other Products]
 UniProt Related Accession #    Q99714 [Other Products]
 Molecular Weight    25,984 Da
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 NCBI Official Full Name    3-hydroxyacyl-CoA dehydrogenase type-2 isoform 2
 NCBI Official Synonym Full Names    hydroxysteroid (17-beta) dehydrogenase 10
 NCBI Official Symbol    HSD17B10 [Similar Products]
 NCBI Official Synonym Symbols   
ABAD; CAMR; ERAB; HCD2; MHBD; HADH2; MRPP2; MRX17; MRX31; SCHAD; MRXS10; SDR5C1; 17b-HSD10; DUPXp11.22
[Similar Products]
 NCBI Protein Information    3-hydroxyacyl-CoA dehydrogenase type-2
 UniProt Protein Name    3-hydroxyacyl-CoA dehydrogenase type-2
 UniProt Synonym Protein Names   
17-beta-hydroxysteroid dehydrogenase 10 (EC:1.1.1.51); 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase (EC:1.1.1.178); 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Short chain dehydrogenase/reductase family 5C member 1; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH
 UniProt Gene Name    HSD17B10 [Similar Products]
 UniProt Synonym Gene Names    ERAB; HADH2; MRPP2; SCHAD; SDR5C1; XH98G2; 17-beta-HSD 10; Mitochondrial RNase P protein 2 [Similar Products]
 UniProt Entry Name    HCD2_HUMAN
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 NCBI Summary for ABAD    This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]
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 UniProt Comments for ABAD    HADH2: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Defects in HSD17B10 are the cause of 2-methyl-3- hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency). MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills. Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10). MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior. A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17); also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub- average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X- linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.178; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Oxidoreductase; EC 1.1.1.51; EC 1.1.1.35

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: mitochondrion; mitochondrial matrix; endoplasmic reticulum; cytoplasm; mitochondrial inner membrane; plasma membrane

Molecular Function: 3(or 17)beta-hydroxysteroid dehydrogenase activity; protein binding; 7-alpha-hydroxysteroid dehydrogenase activity; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity

Biological Process: tRNA processing; branched chain family amino acid catabolic process; lipid metabolic process

Disease: Mental Retardation, X-linked, Syndromic 10; 17-beta-hydroxysteroid Dehydrogenase X Deficiency
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Product References and Citations for anti-ABAD antibody

   FASEB J. 19 (6), 597-598 (2005) J. Mol. Biol. 342 (3), 943-952 (2004) Science 304 (5669), 448-452 (2004) FEBS Lett. 451 (3), 238-242 (1999) J. Biol. Chem. 274 (21), 15014-15019 (1999)
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 Research Articles on ABAD    1. loss of HSD10 causes impaired mitochondrial precursor transcript processing which may explain mitochondrial dysfunction observed in HSD10 disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ABAD antibodyDiseases associated with anti-ABAD antibody
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >10 publications with ABAD and Neurobehavioral Manifestations
 Cardiovascular Diseases Antibodies  >5 publications with ABAD and Cardiovascular Diseases
 Fatty Liver Antibodies  >3 publications with ABAD and Fatty Liver
 Liver Diseases Antibodies  >2 publications with ABAD and Liver Diseases
 Heart Diseases Antibodies  >2 publications with ABAD and Heart Diseases
 Hydroxyacyl-CoA Dehydrogenase, Type 2, Deficiency Antibodies  >2 publications with ABAD and Hydroxyacyl-CoA Dehydrogenase, Type 2, Deficiency
 Infertility, Male Antibodies  >1 publications with ABAD and Infertility, Male
 Learning Disorders Antibodies  >1 publications with ABAD and Learning Disorders
 Necrosis Antibodies  >1 publications with ABAD and Necrosis
 Hyperplasia Antibodies  >1 publications with ABAD and Hyperplasia
Organs/Tissues associated with anti-ABAD antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with ABAD and Brain
 Blood Antibodies  >7 publications with ABAD and Blood
 Muscle Antibodies  >6 publications with ABAD and Muscle
 Liver Antibodies  >6 publications with ABAD and Liver
 Prostate Antibodies  >5 publications with ABAD and Prostate
 Testis Antibodies  >3 publications with ABAD and Testis
 Nerve Antibodies  >3 publications with ABAD and Nerve
 Vascular Antibodies  >3 publications with ABAD and Vascular
 Heart Antibodies  >3 publications with ABAD and Heart
 Intestine Antibodies  >2 publications with ABAD and Intestine
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