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anti-ABAT antibody :: Rabbit ABAT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS129841
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABAT, Polyclonal Antibody

 Also Known As   

ABAT Polyclonal Antibody

 Product Synonym Names    GABAT; NPD009; GABA-AT
 Product Gene Name   

anti-ABAT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613163
 3D Structure    ModBase 3D Structure for P80404
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human ABAT
 Calculated Molecular Weight    56kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-ABAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ABAT antibody

   4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
 Product Categories/Family for anti-ABAT antibody    Polyclonal
 Applications Tested/Suitable for anti-ABAT antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ABAT antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
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 Western Blot (WB) of anti-ABAT antibody    Western blot analysis of extracts of various cell lines, using ABAT antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
anti-ABAT antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ABAT antibody    Immunohistochemistry of paraffin-embedded rat kidney using ABAT antibody at dilution of 1:100 (40x lens).
anti-ABAT antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ABAT antibody    Immunohistochemistry of paraffin-embedded human liver injury using ABAT antibody at dilution of 1:100 (40x lens).
anti-ABAT antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ABAT antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using ABAT antibody at dilution of 1:100 (40x lens).
anti-ABAT antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ABAT antibody    Immunofluorescence analysis of A549 cells using ABAT antibody. Blue: DAPI for nuclear staining.
anti-ABAT antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ABAT. It may not necessarily be applicable to this product.
 NCBI GI #    48429239
 NCBI GeneID    18
 NCBI Accession #    P80404.3 [Other Products]
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 UniProt Primary Accession #    P80404 [Other Products]
 UniProt Secondary Accession #    Q16260; Q8N5W2; Q96BG2; Q99800; A8K386 [Other Products]
 UniProt Related Accession #    P80404 [Other Products]
 Molecular Weight    500
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 NCBI Official Full Name    4-aminobutyrate aminotransferase, mitochondrial
 NCBI Official Synonym Full Names    4-aminobutyrate aminotransferase
 NCBI Official Symbol    ABAT [Similar Products]
 NCBI Official Synonym Symbols   
GABAT; NPD009; GABA-AT
[Similar Products]
 NCBI Protein Information    4-aminobutyrate aminotransferase, mitochondrial; GABA transferase; GABA transaminase; GABA aminotransferase; 4-aminobutyrate transaminase; gamma-amino-N-butyrate transaminase; (S)-3-amino-2-methylpropionate transaminase
 UniProt Protein Name    4-aminobutyrate aminotransferase, mitochondrial
 UniProt Synonym Protein Names   
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22); GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT
 UniProt Gene Name    ABAT [Similar Products]
 UniProt Synonym Gene Names    GABAT; GABA-AT; GABA transaminase; GABA-T [Similar Products]
 UniProt Entry Name    GABT_HUMAN
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 NCBI Summary for ABAT    4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABAT    ABAT: Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Defects in ABAT are a cause of GABA transaminase deficiency (GABATD). The phenotype of this deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Carbohydrate Metabolism - butanoate; EC 2.6.1.19; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; Transferase; Other Amino Acids Metabolism - beta-alanine; EC 2.6.1.22

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: neuron projection; mitochondrion; mitochondrial matrix; 4-aminobutyrate transaminase complex

Molecular Function: protein homodimerization activity; succinate-semialdehyde dehydrogenase binding; (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; pyridoxal phosphate binding

Biological Process: response to nicotine; copulation; response to drug; synaptic transmission; neurotransmitter catabolic process; response to ethanol; behavioral response to cocaine; neurotransmitter secretion; response to hypoxia; locomotory behavior; negative regulation of blood pressure; gamma-aminobutyric acid catabolic process; response to iron ion

Disease: Gaba-transaminase Deficiency
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 Research Articles on ABAT    1. Findings point to a possible role of ABAT gene-regulated GABA catabolism for an altered processing of somatosensory stimuli as a potential vulnerability marker for affective disorders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABAT antibodyPathways associated with anti-ABAT antibody
 Reference Product  PubMed Publications
 ALDH9A1 antibody  >1 publications with ABAT and ALDH9A1
 GAD1 antibody  >1 publications with ABAT and GAD1
 GAD2 antibody  >1 publications with ABAT and GAD2
 ALDH5A1 antibody  >1 publications with ABAT and ALDH5A1
 Products by Pathway  Pathway Diagram
 4-aminobutyrate Degradation Pathway antibodies  4-aminobutyrate Degradation Pathway Diagram
 4-aminobutyrate Degradation Pathway antibodies  4-aminobutyrate Degradation Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Degradation Of GABA Pathway antibodies  Degradation Of GABA Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
Diseases associated with anti-ABAT antibodyOrgans/Tissues associated with anti-ABAT antibody
 Disease Name  Pubmed Publications
 Genetic Predisposition to Disease Antibodies  >5 publications with ABAT and Genetic Predisposition to Disease
 Brain Diseases Antibodies  >4 publications with ABAT and Brain Diseases
 Cardiovascular Diseases Antibodies  >3 publications with ABAT and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with ABAT and Kidney Diseases
 Necrosis Antibodies  >2 publications with ABAT and Necrosis
 Autistic Disorder Antibodies  >2 publications with ABAT and Autistic Disorder
 Neurotoxicity Syndromes Antibodies  >1 publications with ABAT and Neurotoxicity Syndromes
 Hypertension Antibodies  >1 publications with ABAT and Hypertension
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with ABAT and Drug-Related Side Effects and Adverse Reactions
 Inflammation Antibodies  >1 publications with ABAT and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >12 publications with ABAT and Bone
 Blood Antibodies  >8 publications with ABAT and Blood
 Brain Antibodies  >7 publications with ABAT and Brain
 Muscle Antibodies  >5 publications with ABAT and Muscle
 Liver Antibodies  >5 publications with ABAT and Liver
 Kidney Antibodies  >2 publications with ABAT and Kidney
 Lymph Antibodies  >1 publications with ABAT and Lymph
 Lymph Node Antibodies  >1 publications with ABAT and Lymph Node
 Skin Antibodies  >1 publications with ABAT and Skin
 Vascular Antibodies  >1 publications with ABAT and Vascular
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