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anti-ABCA1 antibody :: Rabbit ABCA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176404
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCA1, Polyclonal Antibody

 Also Known As   

Anti-ABCA1 antibody

 Product Synonym Names    ATP-binding cassette sub-family A member 1; ATP-binding cassette, sub-family A(ABC1), member 1; ABC 1 antibody; ABC Transporter 1 antibody; ABC-1 antibody; ABC1 antibody; ABCA 1 antibody; ABCA1 antibody; ABCA1_HUMAN antibody; ATP binding Cassette 1 antibody; ATP binding cassette sub family A ABC1 member 1 antibody; ATP binding cassette sub family A member 1 antibody; ATP binding cassette sub-family A member 1 antibody; ATP binding Cassette Transporter 1 antibody; ATP-binding Cassette 1 antibody; ATP-binding cassette sub-family A member 1 antibody; ATP-binding Cassette Transporter 1 antibody; CERP antibody; Cholesterol Efflux Regulatory Protein antibody; FLJ14958 antibody; HDLDT1 antibody; Membrane bound antibody; MGC164864 antibody; MGC165011 antibody; TD antibody; TGD antibody
 Product Gene Name   

anti-ABCA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene+604091
 3D Structure    ModBase 3D Structure for O95477
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human ABCA1 (2219-2236aa NFAKDQSDDDHLKDLSLH), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ABCA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ABCA1 antibody

   Description: Rabbit IgG polyclonal antibody for ATP-binding cassette sub-family A member 1(ABCA1) detection. Tested with WB in Human, Mouse, Rat.
Background: ABCA1(ATP-binding cassette, sub-family A(ABC1), member 1), also known as ABC1, the cholesterol efflux regulatory protein(CERP), is a protein which in humans is encoded by the ABCA1 gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette(ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes,contains 2,261 amino acids. Dot blot analysis of 50 tissues revealed ubiquitous expression of ABCA1 mRNA, with highest expression in placenta, liver, lung, adrenal glands, and all fetal tissues examined, and lowest expression in kidney, pancreas, pituitary, mammary gland, and bone marrow. This protein is a member of the ABCA subfamily. Members of the ABCA subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesterolefflux  pump in the cellular lipid removal pathway. Using human ABCA1 expressed in the membrane fraction of sf9 insect cells, Szakacs et al. found specific, Mg(2+)-dependent ATP binding and low basal ATPase activity. Addition of potential lipid substrates or lipid acceptors did not modify the ATPase activity or nucleotide occlusion by ABCA1. Szakacs et al. speculated that ABCA1 may be a regulatory protein or may require other protein partners for full activation.
 Applications Tested/Suitable for anti-ABCA1 antibody   

Western Blot (WB)

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 Western Blot (WB) of anti-ABCA1 antibody    Anti-ABCA1 antibody, Western blotting
Lane 1: Rat Brain Tissue Lysate
Lane 2: HT1080 Cell Lysate
Lane 3: HELA Cell Lysate
anti-ABCA1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ABCA1. It may not necessarily be applicable to this product.
 NCBI GI #    308153644
 NCBI GeneID    19
 NCBI Accession #    O95477.3 [Other Products]
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 UniProt Primary Accession #    O95477 [Other Products]
 UniProt Secondary Accession #    Q5VX33; Q96S56; Q96T85; Q9NQV4; Q9UN06; Q9UN07; Q9UN08; Q9UN09 [Other Products]
 UniProt Related Accession #    O95477 [Other Products]
 Molecular Weight    254,302 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family A member 1
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family A (ABC1), member 1
 NCBI Official Symbol    ABCA1 [Similar Products]
 NCBI Official Synonym Symbols   
TGD; ABC1; CERP; ABC-1; HDLDT1
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family A member 1; membrane-bound; ATP-binding cassette transporter A1; cholesterol efflux regulatory protein
 UniProt Protein Name    ATP-binding cassette sub-family A member 1
 UniProt Synonym Protein Names   
ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein
 Protein Family    ABC transporter A family
 UniProt Gene Name    ABCA1 [Similar Products]
 UniProt Synonym Gene Names    ABC1; CERP; ABC-1; ATP-binding cassette 1 [Similar Products]
 UniProt Entry Name    ABCA1_HUMAN
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 NCBI Summary for ABCA1    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCA1    ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Transporter; Vesicle; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; integral to plasma membrane; endocytic vesicle; plasma membrane; phagocytic vesicle; lipid raft; external side of plasma membrane

Molecular Function: apolipoprotein A-I receptor activity; ATPase activity; cholesterol binding; apolipoprotein binding; ATPase binding; small GTPase binding; apolipoprotein A-I binding; protein binding; syntaxin binding; phospholipid transporter activity; cholesterol transporter activity; anion transmembrane transporter activity; phospholipid binding; ATP binding; receptor binding

Biological Process: response to drug; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; intracellular cholesterol transport; lipoprotein metabolic process; cholesterol efflux; cellular lipid metabolic process; endosome transport; phospholipid translocation; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; platelet dense granule organization and biogenesis; lysosome organization and biogenesis; response to low density lipoprotein stimulus; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; interleukin-1 beta secretion; phagocytosis, engulfment; response to nutrient; phospholipid homeostasis; peptide secretion

Disease: Hypoalphalipoproteinemia, Primary; Tangier Disease; Hypercholesterolemia, Familial
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 Research Articles on ABCA1    1. This study suggests that ABCA1 rs1883025 variants are not associated with nAMD or PCV in a Chinese population, which is likely due to an ethnic difference.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ABCA1 antibodyDiseases associated with anti-ABCA1 antibody
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >727 publications with ABCA1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >537 publications with ABCA1 and Cardiovascular Diseases
 Dyslipidemias Antibodies  >258 publications with ABCA1 and Dyslipidemias
 Tangier Disease Antibodies  >204 publications with ABCA1 and Tangier Disease
 Inflammation Antibodies  >204 publications with ABCA1 and Inflammation
 Coronary Disease Antibodies  >172 publications with ABCA1 and Coronary Disease
 Familial HDL deficiency Antibodies  >146 publications with ABCA1 and Familial HDL deficiency
 Liver Diseases Antibodies  >143 publications with ABCA1 and Liver Diseases
 Heart Diseases Antibodies  >134 publications with ABCA1 and Heart Diseases
 Hypoalphalipoproteinemias Antibodies  >129 publications with ABCA1 and Hypoalphalipoproteinemias
Organs/Tissues associated with anti-ABCA1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >811 publications with ABCA1 and Liver
 Blood Antibodies  >706 publications with ABCA1 and Blood
 Vascular Antibodies  >278 publications with ABCA1 and Vascular
 Brain Antibodies  >167 publications with ABCA1 and Brain
 Intestine Antibodies  >110 publications with ABCA1 and Intestine
 Kidney Antibodies  >84 publications with ABCA1 and Kidney
 Muscle Antibodies  >78 publications with ABCA1 and Muscle
 Bone Antibodies  >71 publications with ABCA1 and Bone
 Lung Antibodies  >70 publications with ABCA1 and Lung
 Bone Marrow Antibodies  >67 publications with ABCA1 and Bone Marrow
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