NP_525023.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
184,286 Da
NCBI Official Full Name
ATP-binding cassette sub-family A member 6
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family A (ABC1), member 6
NCBI Official Synonym Symbols
NCBI Protein Information
ATP-binding cassette sub-family A member 6; ABC transporter ABCA6; ATP-binding cassette A6
UniProt Protein Name
ATP-binding cassette sub-family A member 6
UniProt Entry Name
ABCA6_HUMAN
NCBI Summary for ABCA6
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA6
Function: Probable transporter which may play a role in macrophage lipid homeostasis.
Subcellular location: Membrane; Multi-pass membrane protein
Potential.
Tissue specificity: Widely expressed with higher expression in liver. Ref.1 Ref.2
Developmental stage: Expressed in fetal kidney, lung and liver. Ref.2
Induction: Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages. Ref.5
Sequence similarities: Belongs to the ABC transporter superfamily. ABCA family.Contains 2 ABC transporter domains.
Sequence caution: The sequence AAM77557.1 differs from that shown. Reason: Frameshift at positions 998 and 1000. The sequence AAM77558.1 differs from that shown. Reason: Frameshift at positions 998 and 1000. The sequence BAC04994.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on ABCA6
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Products associated with anti-ABCA6 antibody
Pathways associated with anti-ABCA6 antibody
Diseases associated with anti-ABCA6 antibody
Organs/Tissues associated with anti-ABCA6 antibody
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