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anti-ABCB4 antibody :: Rabbit anti-Human ABCB4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176074
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCB4, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-ABCB4 antibody

 Product Synonym Names    Multidrug resistance protein 3; ATP-binding cassette, sub-family B(MDR/TAP), member 4; ABC 21 antibody; ABC B4 antibody; ABC21 antibody; ABCB 4 antibody; Abcb4 antibody; ABCB4 protein antibody; ATP binding cassette sub family B MDR/TAP member 4 antibody; ATP binding cassette sub family B member 4 antibody; ATP-binding cassette sub-family B member 4 antibody; MDR 3 antibody; MDR2 antibody; MDR2/3 antibody; MDR3 antibody; MDR3 P glycoprotein antibody; MDR3 P gp antibody; MDR3_HUMAN antibody; Multidrug resistance protein 3 antibody; Multiple drug resistance 3 antibody; P glycoprotein 3 antibody; P-glycoprotein 3 antibody; PFIC 3 antibody; PFIC3 antibody; PGY 3 antibody; PGY3 antibody
 Product Gene Name   

anti-ABCB4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614972
 3D Structure    ModBase 3D Structure for P21439
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Gene Name    ATP-binding cassette, sub-family B (MDR/TAP), member 4
 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human ABCB4 (1-20aa MDLEAAKNGTAWRPTSAEGD).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ABCB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ABCB4 antibody

   Description: Rabbit IgG polyclonal antibody for Multidrug resistance protein 3(ABCB4) detection. Tested with WB in Human.
Background: Adenosine triphosphate-binding cassette subfamily B, member 4(ABCB4), also called MDR3, is a protein that in humans is encoded by the ABCB4 gene. MDR1 and MDR3 constitute the human P-glycoprotein gene family. The MDR3 gene contains 28 exons and 27 of these contain coding sequences for the two homologous halves of the protein that correlate with functional domains. MDR3 gene mutations represent a genetic factor involved in this peculiar form of cholesterol gallstone disease in adults.
 Applications Tested/Suitable for anti-ABCB4 antibody   

Western Blot (WB)

 Application Notes for anti-ABCB4 antibody    Western Blot:
Concentration:0.1-0.5ug/ml
Tested Species: Hu

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested.
Optimal dilutions should be determiend by end users.
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 Western Blot (WB) of anti-ABCB4 antibody    Anti-ABCB4 antibody, MBS176074, Western blotting
WB: MCF-7 Cell Lysate
anti-ABCB4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ABCB4. It may not necessarily be applicable to this product.
 NCBI GI #    126302568
 NCBI GeneID    5244
 NCBI Accession #    P21439.2 [Other Products]
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 UniProt Primary Accession #    P21439 [Other Products]
 UniProt Secondary Accession #    Q14813; A0A2V7; A4D1D3; A4D1D4; A4D1D5; D6W5P3; D6W5P4 [Other Products]
 UniProt Related Accession #    P21439 [Other Products]
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 NCBI Official Full Name    Multidrug resistance protein 3
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family B (MDR/TAP), member 4
 NCBI Official Symbol    ABCB4 [Similar Products]
 NCBI Official Synonym Symbols   
GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3
[Similar Products]
 NCBI Protein Information    multidrug resistance protein 3; P-glycoprotein 3; multiple drug resistance 3; ATP-binding cassette sub-family B member 4; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3
 UniProt Protein Name    Multidrug resistance protein 3
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family B member 4; P-glycoprotein 3
 Protein Family    ABC transporter B family
 UniProt Gene Name    ABCB4 [Similar Products]
 UniProt Synonym Gene Names    MDR3; PGY3 [Similar Products]
 UniProt Entry Name    MDR3_HUMAN
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 NCBI Summary for ABCB4    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCB4    ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described.

Protein type: Membrane protein, multi-pass; Transporter, ABC family; Hydrolase; EC 3.6.3.44; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: intercellular canaliculus; membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; xenobiotic-transporting ATPase activity; ATP binding

Biological Process: response to drug; transport; multidrug transport; xenobiotic transport; lipid metabolic process; cellular lipid metabolic process; transmembrane transport

Disease: Gallbladder Disease 1; Cholestasis, Progressive Familial Intrahepatic, 3; Cholestasis, Intrahepatic, Of Pregnancy 3
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 Research Articles on ABCB4    1. We identified disease-associated variants of ABCB4 involved in the phosphorylation of its N-terminal domain and leading to decreased phosphatidylcholine secretion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABCB4 antibodyPathways associated with anti-ABCB4 antibody
 Reference Product  PubMed Publications
 NR1H4 antibody  >4 publications with ABCB4 and NR1H4
 PPARA antibody  >1 publications with ABCB4 and PPARA
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
Diseases associated with anti-ABCB4 antibodyOrgans/Tissues associated with anti-ABCB4 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >108 publications with ABCB4 and Liver Diseases
 Cholestasis Antibodies  >106 publications with ABCB4 and Cholestasis
 Intrahepatic Cholestasis of Pregnancy Antibodies  >38 publications with ABCB4 and Intrahepatic Cholestasis of Pregnancy
 Fibrosis Antibodies  >36 publications with ABCB4 and Fibrosis
 Liver Cirrhosis Antibodies  >34 publications with ABCB4 and Liver Cirrhosis
 Cholangitis Antibodies  >28 publications with ABCB4 and Cholangitis
 Disease Models, Animal Antibodies  >28 publications with ABCB4 and Disease Models, Animal
 Inflammation Antibodies  >24 publications with ABCB4 and Inflammation
 Liver Cirrhosis, Biliary Antibodies  >23 publications with ABCB4 and Liver Cirrhosis, Biliary
 Cholangitis, Sclerosing Antibodies  >21 publications with ABCB4 and Cholangitis, Sclerosing
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >151 publications with ABCB4 and Liver
 Blood Antibodies  >40 publications with ABCB4 and Blood
 Intestine Antibodies  >11 publications with ABCB4 and Intestine
 Brain Antibodies  >10 publications with ABCB4 and Brain
 Mixed Antibodies  >9 publications with ABCB4 and Mixed
 Kidney Antibodies  >7 publications with ABCB4 and Kidney
 Muscle Antibodies  >5 publications with ABCB4 and Muscle
 Embryonic Tissue Antibodies  >4 publications with ABCB4 and Embryonic Tissue
 Testis Antibodies  >2 publications with ABCB4 and Testis
 Pancreas Antibodies  >1 publications with ABCB4 and Pancreas
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