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anti-ABCB4 antibody :: Rabbit anti-Human, Mouse ABCB4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS648773 anti-ABCB4 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCB4, Polyclonal Antibody

 Also Known As   

ABCB4, ID (ABCB4, MDR3, PGY3, Multidrug resistance protein 3, ATP-binding cassette sub-family B member 4, P-glycoprotein 3)

 Product Synonym Names    Anti -ABCB4, ID (ABCB4, MDR3, PGY3, Multidrug resistance protein 3, ATP-binding cassette sub-family B member 4, P-glycoprotein 3)
 Product Gene Name   

anti-ABCB4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (87031361..87105019, complement). Location: 7q21.1
 OMIM    171060
 3D Structure    ModBase 3D Structure for P21439
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Human, mouse
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    ABCB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 632~661 amino acids from the central region of human ABCB4.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ABCB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ABCB4 antibody

   The membrane-associated protein encoded ABCB4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
 Product Categories/Family for anti-ABCB4 antibody    Antibodies; Abs to Multi Drug Resistance (MDR)
 Applications Tested/Suitable for anti-ABCB4 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ABCB4 antibody    Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
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NCBI/Uniprot data below describe general gene information for ABCB4. It may not necessarily be applicable to this product.
 NCBI GI #    34783320
 NCBI GeneID    5244
 NCBI Accession #    AAH20618.1 [Other Products]
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 UniProt Primary Accession #    P21439 [Other Products]
 UniProt Secondary Accession #    Q14813; A0A2V7; A4D1D3; A4D1D4; A4D1D5; D6W5P3; D6W5P4 [Other Products]
 UniProt Related Accession #    P21439 [Other Products]
 Molecular Weight    141,523 Da [Similar Products]
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 NCBI Official Full Name    ABCB4 protein
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family B (MDR/TAP), member 4
 NCBI Official Symbol    ABCB4 [Similar Products]
 NCBI Official Synonym Symbols   
GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3
[Similar Products]
 NCBI Protein Information    multidrug resistance protein 3; P-glycoprotein 3; multiple drug resistance 3; ATP-binding cassette sub-family B member 4; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3
 UniProt Protein Name    Multidrug resistance protein 3
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family B member 4; P-glycoprotein 3
 Protein Family    ABC transporter B family
 UniProt Gene Name    ABCB4 [Similar Products]
 UniProt Synonym Gene Names    MDR3; PGY3 [Similar Products]
 UniProt Entry Name    MDR3_HUMAN
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 NCBI Summary for ABCB4    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCB4    Function: Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.

Catalytic activity: ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subunit structure: Interacts with HAX1

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Involvement in disease: Cholestasis, progressive familial intrahepatic, 3 (PFIC3) [MIM:602347]: A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.11 Ref.13Cholestasis of pregnancy, intrahepatic 3 (ICP3) [MIM:614972]: A liver disorder of pregnancy. It presents during the second or, more commonly, the third trimester of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. It causes fetal distress, spontaneous premature delivery and intrauterine death. Patients have spontaneous and progressive disappearance of cholestasis after delivery. Cholestasis results from abnormal biliary transport from the liver into the small intestine.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.15 Ref.16Gallbladder disease 1 (GBD1) [MIM:600803]: One of the major digestive diseases. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations in western countries. Most people with gallstones, however, remain asymptomatic through their lifetimes.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.14

Sequence similarities: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Contains 2 ABC transmembrane type-1 domains.Contains 2 ABC transporter domains.

Sequence caution: The sequence CAA84542.1 differs from that shown. Reason: Probable cloning artifact.
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 Research Articles on ABCB4    1. Genotyping of Italian women revealed 2 novel variants of ABCB4 (p.I587DfsX603, p.I738LfsX744) associated with intrahepatic cholestasis of pregnancy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABCB4 antibodyPathways associated with anti-ABCB4 antibody
 Reference Product  PubMed Publications
 NR1H4 antibody  >3 publications with ABCB4 and NR1H4
 PPARA antibody  >1 publications with ABCB4 and PPARA
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
Diseases associated with anti-ABCB4 antibodyOrgans/Tissues associated with anti-ABCB4 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >95 publications with ABCB4 and Liver Diseases
 Cholestasis Antibodies  >87 publications with ABCB4 and Cholestasis
 Fibrosis Antibodies  >34 publications with ABCB4 and Fibrosis
 Liver Cirrhosis Antibodies  >33 publications with ABCB4 and Liver Cirrhosis
 Cholangitis Antibodies  >26 publications with ABCB4 and Cholangitis
 Disease Models, Animal Antibodies  >24 publications with ABCB4 and Disease Models, Animal
 Inflammation Antibodies  >23 publications with ABCB4 and Inflammation
 Liver Cirrhosis, Biliary Antibodies  >22 publications with ABCB4 and Liver Cirrhosis, Biliary
 Neoplasms Antibodies  >20 publications with ABCB4 and Neoplasms
 Pruritus Antibodies  >16 publications with ABCB4 and Pruritus
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >132 publications with ABCB4 and Liver
 Blood Antibodies  >36 publications with ABCB4 and Blood
 Intestine Antibodies  >10 publications with ABCB4 and Intestine
 Mixed Antibodies  >7 publications with ABCB4 and Mixed
 Brain Antibodies  >6 publications with ABCB4 and Brain
 Kidney Antibodies  >5 publications with ABCB4 and Kidney
 Muscle Antibodies  >4 publications with ABCB4 and Muscle
 Embryonic Tissue Antibodies  >2 publications with ABCB4 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with ABCB4 and Pancreas
 Testis Antibodies  >1 publications with ABCB4 and Testis
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