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anti-ABCB5 antibody :: Rabbit anti-Human ABCB5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002586
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCB5, Polyclonal Antibody

★Popular Item★
 Also Known As   

ABCB5 Antibody

 Product Synonym Names    ATP-binding cassette sub-family B member 5; ABCB5; ABCB5 P-gp; P-glycoprotein ABCB5
 Product Gene Name   

anti-ABCB5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611785
 3D Structure    ModBase 3D Structure for Q2M3G0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purified
 Form/Format    Liquid
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 Immunogen    Recombinant human ATP-binding cassette sub-family B member 5 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-104019
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ABCB5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ABCB5 antibody

   Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
 Applications Tested/Suitable for anti-ABCB5 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ABCB5 antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-ABCB5 antibody    Immunohistochemistry of paraffin-embedded human liver cancer using MBS7002586 at dilution of 1:100
anti-ABCB5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ABCB5 antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS7002586 at dilution of 1:100
anti-ABCB5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ABCB5 antibody    Immunofluorescent analysis of A431 cells using MBS7002586 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ABCB5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ABCB5. It may not necessarily be applicable to this product.
 NCBI GI #    255708477
 NCBI GeneID    340273
 NCBI Accession #    NP_001157413.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001163941.1 [Other Products]
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 UniProt Primary Accession #    Q2M3G0 [Other Products]
 UniProt Secondary Accession #    Q2M3I5; Q5I5Q7; Q5I5Q8; Q6KG50; A4D131; A7BKA4; B5MD19; B7WPL1; F8QQP8; F8QQP9; J3KQ04 [Other Products]
 UniProt Related Accession #    Q2M3G0 [Other Products]
 Molecular Weight    89,832 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family B member 5 isoform 1
 NCBI Official Synonym Full Names    ATP binding cassette subfamily B member 5
 NCBI Official Symbol    ABCB5 [Similar Products]
 NCBI Official Synonym Symbols   
ABCB5beta; EST422562; ABCB5alpha
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family B member 5
 UniProt Protein Name    ATP-binding cassette sub-family B member 5
 UniProt Synonym Protein Names   
ABCB5 P-gp; P-glycoprotein ABCB5
 Protein Family    ABC transporter B family
 UniProt Gene Name    ABCB5 [Similar Products]
 UniProt Entry Name    ABCB5_HUMAN
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 NCBI Summary for ABCB5    ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for ABCB5    ABCB5: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, ABC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; efflux transmembrane transporter activity

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cell differentiation; compound eye corneal lens development; metabolic process; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; regulation of membrane potential; transmembrane transport
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 Research Articles on ABCB5    1. ABCB5 alleles alter susceptibility to haloperidol-induced toxicity (HIT) in mouse and humans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABCB5 antibodyPathways associated with anti-ABCB5 antibody
 Reference Product  PubMed Publications
 SOCS1 antibody  >1 publications with ABCB5 and SOCS1
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with anti-ABCB5 antibodyOrgans/Tissues associated with anti-ABCB5 antibody
 Disease Name  Pubmed Publications
 Melanoma Antibodies  >65 publications with ABCB5 and Melanoma
 Disease Models, Animal Antibodies  >4 publications with ABCB5 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with ABCB5 and Liver Diseases
 Nervous System Diseases Antibodies  >3 publications with ABCB5 and Nervous System Diseases
 Inflammation Antibodies  >2 publications with ABCB5 and Inflammation
 Necrosis Antibodies  >2 publications with ABCB5 and Necrosis
 Pregnancy Complications Antibodies  >1 publications with ABCB5 and Pregnancy Complications
 Neurotoxicity Syndromes Antibodies  >1 publications with ABCB5 and Neurotoxicity Syndromes
 Liver Failure Antibodies  >1 publications with ABCB5 and Liver Failure
 Hypertension Antibodies  >1 publications with ABCB5 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >30 publications with ABCB5 and Skin
 Testis Antibodies  >3 publications with ABCB5 and Testis
 Intestine Antibodies  >2 publications with ABCB5 and Intestine
 Brain Antibodies  >2 publications with ABCB5 and Brain
 Kidney Antibodies  >1 publications with ABCB5 and Kidney
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