NP_004987.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
multidrug resistance-associated protein 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 1
NCBI Protein Information
multidrug resistance-associated protein 1
UniProt Protein Name
Multidrug resistance-associated protein 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter
UniProt Synonym Gene Names
NCBI Summary for ABCC1
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
UniProt Comments for ABCC1
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Product References and Citations for anti-ABCC1 antibody
Zhou H, Lin C, Zhang Y, Zhang X, Zhang C, Zhang P, Xie X, Ren Z; Journal: Cell Prolif. miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression.
Research Articles on ABCC1
Precautions
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Pathways associated with anti-ABCC1 antibody
Diseases associated with anti-ABCC1 antibody
Organs/Tissues associated with anti-ABCC1 antibody
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