NP_000383.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
canalicular multispecific organic anion transporter 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 2
NCBI Protein Information
canalicular multispecific organic anion transporter 1
UniProt Protein Name
Canalicular multispecific organic anion transporter 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2
UniProt Synonym Gene Names
NCBI Summary for ABCC2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC2
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Research Articles on ABCC2
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Products associated with anti-ABCC2 antibody
Pathways associated with anti-ABCC2 antibody
Diseases associated with anti-ABCC2 antibody
Organs/Tissues associated with anti-ABCC2 antibody
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