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anti-ABCC8 antibody :: Rabbit anti-Mouse ABCC8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9128228
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCC8, Polyclonal Antibody

 Also Known As   

ABCC8 Polyclonal Antibody

 Product Gene Name   

anti-ABCC8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    240800
 3D Structure    ModBase 3D Structure for Q09428
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Purity/Purification    Affinity Purification
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 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human ABCC8
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-ABCC8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ABCC8 antibody

   The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.
 Applications Tested/Suitable for anti-ABCC8 antibody   

Western Blot (WB)

 Application Notes for anti-ABCC8 antibody    WB 1:500 - 1:2000
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 Western Blot (WB) of anti-ABCC8 antibody    Western blot analysis of extracts of mouse pancreas, using ABCC8 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
anti-ABCC8 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ABCC8. It may not necessarily be applicable to this product.
 NCBI GI #    118582255
 NCBI GeneID    6833
 NCBI Accession #    NP_000343.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000352.4 [Other Products]
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 UniProt Primary Accession #    Q09428 [Other Products]
 UniProt Secondary Accession #    O75948; Q16583; A6NMX8; E3UYX6 [Other Products]
 UniProt Related Accession #    Q09428 [Other Products]
 Molecular Weight    177kDa
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 NCBI Official Full Name    ATP-binding cassette sub-family C member 8 isoform 2
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family C (CFTR/MRP), member 8
 NCBI Official Symbol    ABCC8 [Similar Products]
 NCBI Official Synonym Symbols   
HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; TNDM2; SUR1delta2
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family C member 8
 UniProt Protein Name    ATP-binding cassette sub-family C member 8
 UniProt Synonym Protein Names   
Sulfonylurea receptor 1
 Protein Family    ABC transporter C family
 UniProt Gene Name    ABCC8 [Similar Products]
 UniProt Synonym Gene Names    HRINS; SUR; SUR1 [Similar Products]
 UniProt Entry Name    ABCC8_HUMAN
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 NCBI Summary for ABCC8    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
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 UniProt Comments for ABCC8    ABCC8: a multi-pass membrane protein subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Associates with Kir6.2. Defects in ABCC8 are a cause of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) [MIM:601820, 256450], and may contribute to non-insulin-dependent diabetes mellitus (NIDDM) in Northern European Caucasians. Two alternatively spliced human isoforms have been described.

Protein type: Transporter, ABC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: voltage-gated potassium channel complex; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; sulfonylurea receptor activity; potassium ion transmembrane transporter activity; ATP binding

Biological Process: synaptic transmission; carbohydrate metabolic process; energy reserve metabolic process; signal transduction; transmembrane transport; regulation of insulin secretion; potassium ion transport

Disease: Hyperinsulinemic Hypoglycemia, Familial, 1; Diabetes Mellitus, Transient Neonatal, 2; Diabetes Mellitus, Permanent Neonatal; Hypoglycemia, Leucine-induced; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on ABCC8    1. Paternally inherited heterozygous ABCC8/KCNJ11 mutations can manifest as a wide spectrum of congenital hyperinsulinism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABCC8 antibodyPathways associated with anti-ABCC8 antibody
 Reference Product  PubMed Publications
 KCNJ11 antibody  >269 publications with ABCC8 and KCNJ11
 INS antibody  >52 publications with ABCC8 and INS
 KCNJ8 antibody  >7 publications with ABCC8 and KCNJ8
 FOXA2 antibody  >2 publications with ABCC8 and FOXA2
 RAPGEF3 antibody  >1 publications with ABCC8 and RAPGEF3
 RAPGEF4 antibody  >1 publications with ABCC8 and RAPGEF4
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ATP Sensitive Potassium Channels Pathway antibodies  ATP Sensitive Potassium Channels Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
Diseases associated with anti-ABCC8 antibodyOrgans/Tissues associated with anti-ABCC8 antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >251 publications with ABCC8 and Diabetes Mellitus
 Congenital Hyperinsulinism Antibodies  >157 publications with ABCC8 and Congenital Hyperinsulinism
 Diabetes Mellitus, Type 2 Antibodies  >97 publications with ABCC8 and Diabetes Mellitus, Type 2
 Hyperglycemia Antibodies  >48 publications with ABCC8 and Hyperglycemia
 Cardiovascular Diseases Antibodies  >44 publications with ABCC8 and Cardiovascular Diseases
 Diabetes Mellitus, Type 1 Antibodies  >44 publications with ABCC8 and Diabetes Mellitus, Type 1
 Diabetes Mellitus, Transient Neonatal, 2 Antibodies  >27 publications with ABCC8 and Diabetes Mellitus, Transient Neonatal, 2
 Edema Antibodies  >17 publications with ABCC8 and Edema
 Hyperplasia Antibodies  >14 publications with ABCC8 and Hyperplasia
 Seizures Antibodies  >14 publications with ABCC8 and Seizures
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >225 publications with ABCC8 and Pancreas
 Muscle Antibodies  >86 publications with ABCC8 and Muscle
 Brain Antibodies  >84 publications with ABCC8 and Brain
 Heart Antibodies  >66 publications with ABCC8 and Heart
 Bone Antibodies  >6 publications with ABCC8 and Bone
 Eye Antibodies  >2 publications with ABCC8 and Eye
 Lung Antibodies  >2 publications with ABCC8 and Lung
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