NP_005155.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,233 Da
NCBI Official Full Name
ATP-binding cassette sub-family D member 2
NCBI Official Synonym Full Names
ATP binding cassette subfamily D member 2
NCBI Official Synonym Symbols
ALDR; ABC39; ALDL1; ALDRP; hALDR [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family D member 2
UniProt Protein Name
ATP-binding cassette sub-family D member 2
UniProt Synonym Protein Names
Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR
UniProt Synonym Gene Names
UniProt Entry Name
ABCD2_HUMAN
NCBI Summary for ABCD2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCD2
ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, ABC family; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: cytosol; integral to membrane; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome
Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; long-chain fatty acid transporter activity; protein binding; protein homodimerization activity
Biological Process: fatty acid beta-oxidation; long-chain fatty acid transport; positive regulation of fatty acid beta-oxidation; transmembrane transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process
Research Articles on ABCD2
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Products associated with anti-ABCD2 antibody
Pathways associated with anti-ABCD2 antibody
Diseases associated with anti-ABCD2 antibody
Organs/Tissues associated with anti-ABCD2 antibody
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