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anti-ABCG1 antibody :: Rabbit ABCG1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176215
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCG1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-ABCG1 antibody

 Product Synonym Names    ATP-binding cassette sub-family G member 1; ATP-binding cassette, sub-family G(WHITE), member 1; ABC transporter 8 antibody; Abc8 antibody; ABCG1 antibody; ABCG1_HUMAN antibody; ATP-binding cassette sub family G member 1 antibody; ATP-binding cassette sub-family G member 1 antibody; ATP-binding cassette transporter 8 antibody; ATP-binding cassette transporter member 1 of subfamily G antibody; ATP-binding cassette, sub family G WHITE member 1 antibodyhomolog of Drosophila white antibody; MGC34313 antibody; White protein homolog antibody; White protein homolog ATP binding cassette transporter 8 antibody; WHITE1 antibody; wht1 antibody
 Product Gene Name   

anti-ABCG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603076
 3D Structure    ModBase 3D Structure for P45844
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Reacts with: Human
Predicted to work with: Mouse, Rat
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 Specificity    No cross reactivity with other proteins
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human ABCG1 (627-647aa ETCHFQKSEAILRELDVENAK), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ABCG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ABCG1 antibody

   Description: Rabbit IgG polyclonal antibody for ATP-binding cassette sub-family G member 1(ABCG1) detection. Tested with WB in Human, Mouse, Rat.
Background: ABCG1(Atp-binding cassette, subfamily g, member 1) also known as ABC8, ABC TRANSPORTER 8 or WHITE, DROSOPHILA, HOMOLOG OF, is a protein that in humans is encoded by the ABCG1 gene. ABCG1 is a regulator of macrophage cholesterol and phospholipid transport. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette(ABC) transporters.The ABCG1 gene is mapped on 21q22.3. This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. ABCG1 is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. Inhibition of ABCG1 protein expression using an antisense strategy resulted in reduced HDL3-dependent efflux of cholesterol and choline-phospholipids. In macrophages, silencing of GPS2 by RNA interference reduced ABCG1 expression and diminished ABCG1-mediated cholesterol efflux.
 Applications Tested/Suitable for anti-ABCG1 antibody   

Western Blot (WB)

 Application Notes for anti-ABCG1 antibody    Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu
Predicted Species: Ms, Rat
Antigen Retrieval: -

WB: The detection limit for ABCG1 is approximately 5ng/lane under reducing conditions.
Tested Species: In-house tested species with positive results.
Predicted Species: Specices predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
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 Western Blot (WB) of anti-ABCG1 antibody    Anti-ABCG1 antibody, Western blotting
All lanes: Anti ABCG1 at 0.5ug/ml
anti-ABCG1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ABCG1. It may not necessarily be applicable to this product.
 NCBI GI #    17433715
 NCBI GeneID    9619
 NCBI Accession #    P45844.3 [Other Products]
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 UniProt Primary Accession #    P45844 [Other Products]
 UniProt Secondary Accession #    Q86SU8; Q96L76; Q9BXK6; Q9BXK7; Q9BXK8; Q9BXK9; Q9BXL0; Q9BXL1; Q9BXL2; Q9BXL3; Q9BXL4 [Other Products]
 UniProt Related Accession #    P45844 [Other Products]
 Molecular Weight    86,628 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family G member 1
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family G (WHITE), member 1
 NCBI Official Symbol    ABCG1 [Similar Products]
 NCBI Official Synonym Symbols   
ABC8; WHITE1
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family G member 1; ABC transporter 8; homolog of Drosophila white; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; white protein homolog (ATP-binding cassette transporter 8)
 UniProt Protein Name    ATP-binding cassette sub-family G member 1
 UniProt Synonym Protein Names   
ATP-binding cassette transporter 8; White protein homolog
 Protein Family    ABC transporter G family
 UniProt Gene Name    ABCG1 [Similar Products]
 UniProt Synonym Gene Names    ABC8; WHT1 [Similar Products]
 UniProt Entry Name    ABCG1_HUMAN
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 NCBI Summary for ABCG1    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCG1    ABCG1: Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; recycling endosome; intracellular membrane-bound organelle; mitochondrion; integral to plasma membrane; plasma membrane; endosome; external side of plasma membrane

Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; phospholipid transporter activity; protein heterodimerization activity; cholesterol transporter activity; toxin transporter activity; cholesterol binding; phospholipid binding; sterol-transporting ATPase activity; ADP binding; ATP binding

Biological Process: cholesterol metabolic process; detection of hormone stimulus; response to high density lipoprotein stimulus; positive regulation of cholesterol biosynthetic process; intracellular cholesterol transport; cholesterol efflux; lipoprotein metabolic process; response to lipid; response to organic substance; amyloid precursor protein catabolic process; cholesterol homeostasis; reverse cholesterol transport; regulation of transcription, DNA-dependent; phospholipid efflux; transmembrane transport; phospholipid homeostasis
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 Research Articles on ABCG1    1. I human macrophages, polyunsaturated fatty acids such as EPA have an effect on the cholesterol homeostasis in macrophages, and they can change the expression of ABCG1 gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ABCG1 antibodyDiseases associated with anti-ABCG1 antibody
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ABCA Transporters In Lipid Homeostasis Pathway antibodies  ABCA Transporters In Lipid Homeostasis Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >284 publications with ABCG1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >194 publications with ABCG1 and Cardiovascular Diseases
 Inflammation Antibodies  >96 publications with ABCG1 and Inflammation
 Dyslipidemias Antibodies  >54 publications with ABCG1 and Dyslipidemias
 Liver Diseases Antibodies  >51 publications with ABCG1 and Liver Diseases
 Fatty Liver Antibodies  >47 publications with ABCG1 and Fatty Liver
 Hyperlipidemias Antibodies  >35 publications with ABCG1 and Hyperlipidemias
 Necrosis Antibodies  >30 publications with ABCG1 and Necrosis
 Hypercholesterolemia Antibodies  >30 publications with ABCG1 and Hypercholesterolemia
 Nervous System Diseases Antibodies  >27 publications with ABCG1 and Nervous System Diseases
Organs/Tissues associated with anti-ABCG1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >309 publications with ABCG1 and Liver
 Blood Antibodies  >199 publications with ABCG1 and Blood
 Brain Antibodies  >53 publications with ABCG1 and Brain
 Muscle Antibodies  >35 publications with ABCG1 and Muscle
 Lung Antibodies  >34 publications with ABCG1 and Lung
 Intestine Antibodies  >22 publications with ABCG1 and Intestine
 Kidney Antibodies  >22 publications with ABCG1 and Kidney
 Connective Tissue Antibodies  >12 publications with ABCG1 and Connective Tissue
 Spleen Antibodies  >12 publications with ABCG1 and Spleen
 Pancreas Antibodies  >11 publications with ABCG1 and Pancreas
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