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anti-ABHD12 antibody :: Goat ABHD12 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421831
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABHD12, Polyclonal Antibody

 Also Known As   

Goat anti-ABHD12 Antibody

 Product Synonym Names    ABHD12; abhydrolase domain containing 12; ABHD12A; BEM46L2; C20orf22; DKFZP434P106; dJ965G21.2; ABHD12 antibody; abhydrolase domain containing 12 antibody; ABHD12A antibody; BEM46L2 antibody; C20orf22 antibody; DKFZP434P106 antibody; dJ965G21.2 antibody; ABHD12
 Product Gene Name   

anti-ABHD12 antibody

[Similar Products]
 Antibody/Peptide Pairs    ABHD12 peptide (MBS426264) is used for blocking the activity of ABHD12 antibody (MBS421831)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    REFLGKSEPE HQH
 OMIM    612674
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-REFLGKSEPEHQH, from the C Terminus of the protein sequence according to NP_001035937.1; NP_056415.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognize isoform a (NP_001035937.1) only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ABHD12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ABHD12 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ABHD12 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: approx. 40kDa band observed in Mouse Brain and Rat Brain lysates (calculated MW of 45.1kDa according to Human NP_001035937.1 and of 45.3kDa according to Mouse NP_077785.2). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-ABHD12 antibody    (0.3 ug/ ml) staining of Mouse Brain lysate (35 ug/ protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ABHD12 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ABHD12. It may not necessarily be applicable to this product.
 NCBI GI #    109689718
 NCBI GeneID    26090
 NCBI Accession #    NP_001035937.1 [Other Products]
 NCBI Related Accession #    NP_056415.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042472.2 [Other Products]
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 UniProt Secondary Accession #    Q5T710; Q5T711; Q96CR1; Q9BX05; Q9NPX7; Q9UFV6; A6NED4; A6NJ90; A8K450; B4DE71 [Other Products]
 UniProt Related Accession #    Q8N2K0 [Other Products]
 Molecular Weight    41,387 Da
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 NCBI Official Full Name    monoacylglycerol lipase ABHD12 isoform a
 NCBI Official Synonym Full Names    abhydrolase domain containing 12
 NCBI Official Symbol    ABHD12 [Similar Products]
 NCBI Official Synonym Symbols   
PHARC; ABHD12A; BEM46L2; C20orf22; dJ965G21.2
[Similar Products]
 NCBI Protein Information    monoacylglycerol lipase ABHD12
 UniProt Protein Name    Monoacylglycerol lipase ABHD12
 UniProt Synonym Protein Names   
2-arachidonoylglycerol hydrolaseCurated; Abhydrolase domain-containing protein 12Curated
 Protein Family    Monoacylglycerol lipase
 UniProt Gene Name    ABHD12 [Similar Products]
 UniProt Entry Name    ABD12_HUMAN
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 NCBI Summary for ABHD12    This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
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 UniProt Comments for ABHD12    ABHD12: Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways. Defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC). PHARC is a slowly progressive neurologic disorder with a variable phenotype resembling Refsum disease. Clinical features include sensorineural hearing loss, visual problems related to cataracts, retinitis pigmentosa, pes cavus, ataxic and/or spastic gait disturbances with a progressive sensorimotor peripheral neuropathy. Other features include hyporeflexia, hyperreflexia, extensor plantar responses. Belongs to the serine esterase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.23; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: acylglycerol lipase activity

Biological Process: acylglycerol catabolic process; adult walking behavior; phosphatidylserine catabolic process

Disease: Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract
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 Research Articles on ABHD12    1. ABHD12 mutation in 2 PHARC (Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract)patients who suffered from deaf-blindness and dysfunctional central and peripheral nervous systems.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ABHD12 antibodyDiseases associated with anti-ABHD12 antibody
 Products by Pathway  Pathway Diagram
 Arachidonate Production From DAG Pathway antibodies  Arachidonate Production From DAG Pathway Diagram
 Effects Of PIP2 Hydrolysis Pathway antibodies  Effects Of PIP2 Hydrolysis Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Triacylglycerol Degradation Pathway antibodies  Triacylglycerol Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >4 publications with ABHD12 and Abnormalities, Multiple
 Inflammation Antibodies  >4 publications with ABHD12 and Inflammation
 Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract Antibodies  >4 publications with ABHD12 and Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract
 Cardiovascular Diseases Antibodies  >2 publications with ABHD12 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >2 publications with ABHD12 and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >1 publications with ABHD12 and Heart Defects, Congenital
 Kidney Diseases Antibodies  >1 publications with ABHD12 and Kidney Diseases
 Fatty Liver Antibodies  >1 publications with ABHD12 and Fatty Liver
 Necrosis Antibodies  >1 publications with ABHD12 and Necrosis
 Demyelinating Diseases Antibodies  >1 publications with ABHD12 and Demyelinating Diseases
Organs/Tissues associated with anti-ABHD12 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with ABHD12 and Brain
 Liver Antibodies  >2 publications with ABHD12 and Liver
 Blood Antibodies  >2 publications with ABHD12 and Blood
 Heart Antibodies  >1 publications with ABHD12 and Heart
 Eye Antibodies  >1 publications with ABHD12 and Eye
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