NP_001171595.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,912 Da
NCBI Official Full Name
abl interactor 1 isoform k
NCBI Official Synonym Full Names
abl-interactor 1
NCBI Official Synonym Symbols
E3B1; ABI-1; ABLBP4; NAP1BP; SSH3BP; SSH3BP1 [Similar Products]
NCBI Protein Information
abl interactor 1; Abelson interactor 1; Abl-interactor protein 1 long; abl-binding protein 4; eps8 SH3 domain-binding protein; interactor protein AblBP4; nap1 binding protein; spectrin SH3 domain-binding protein 1
UniProt Protein Name
Abl interactor 1
UniProt Synonym Protein Names
Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; Eps8 SH3 domain-binding protein; Eps8-binding protein; Nap1-binding protein; Nap1BP; Spectrin SH3 domain-binding protein 1; e3B1
UniProt Synonym Gene Names
UniProt Entry Name
ABI1_HUMAN
NCBI Summary for ABI1
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
UniProt Comments for ABI1
Abi-1: an SH3-containing adapter protein that regulates c-Abl-mediated phosphorylation of Mena. Binds the SH3 domains of epidermal growth factor receptor kinase substrate (EPS8) and of spectrin. May play a role in fusion of macropinocytic vesicles. Associated with congenital acute monocytic leukemia.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10p11.2
Cellular Component: postsynaptic membrane; cytoskeleton; growth cone; lamellipodium; endoplasmic reticulum; postsynaptic density; intracellular; cell junction; cytosol; nucleus; filopodium
Molecular Function: protein binding; cytoskeletal protein binding; protein complex binding; protein tyrosine kinase activator activity
Biological Process: negative regulation of cell proliferation; somitogenesis; peptidyl-tyrosine phosphorylation; actin polymerization and/or depolymerization; innate immune response; vascular endothelial growth factor receptor signaling pathway; cell motility; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on ABI1
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Pathways associated with anti-ABI1 antibody
Diseases associated with anti-ABI1 antibody
Organs/Tissues associated with anti-ABI1 antibody
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