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Add To Compare List anti-ABI2 antibody :: Rabbit ABI2 Polyclonal Antibody Catalog # MBS176106 Unit / Price 0.1 mg / $460 +1 FREE 8GB USB 5x0.1 mg / $1,880 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name ABI2, Polyclonal Antibody Full Product Name Anti-ABI2 antibody Product Synonym Names Abl interactor 2; abl-interactor 2; Abelson interactor 2 antibody; ABI 2 antibody; ABI2B antibody; Abl binding protein 3 antibody; Abl interacting protein 1(SH3 containing protein) antibody; Abl interactor 2 antibody; Abl interactor protein 2b antibody; AblBP3 antibody; AIP 1 antibody; Arg binding protein 1 antibody; Arg protein tyrosine kinase binding protein antibody; ArgBP1 antibody; ARGBPIA antibody; ArgBPIB antibody; OTTHUMP00000163783 antibody; OTTHUMP00000163784 antibody; OTTHUMP00000206182 antibody; OTTHUMP00000206183 antibody; OTTHUMP00000206184 antibody; OTTHUMP00000206185 antibody; SSH3BP2 antibody Product Gene Name anti-ABI2 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM 606442 3D Structure ModBase 3D Structure for Q9NYB9 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Purity/Purification Immunogen affinity purified. Form/Format Lyophilized Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human ABI2 (158-173aa RFKVSTQNMKMGGLPR), identical to the related mouse and rat sequences. Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml. Preparation and Storage At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. ISO Certification Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory. Other Notes Small volumes of anti-ABI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-ABI2 antibody Description: Rabbit IgG polyclonal antibody for Abl interactor 2(ABI2) detection. Tested with WB in Human, Mouse, Rat.Background: ABI2(ABL Interactor 2), is a protein that in humans is encoded by the ABI2 gene. By analysis of a YAC and a BAC, Machado et al.(2000) mapped the ABI2 gene to 2q31-q33. ABI2 possesses a basic N terminus with homology to a homeodomain protein; a central serine-rich region; 3 PEST sequences, which are implicated in susceptibility to protein degradation; several proline-rich stretches; and an acidic C terminus with multiple phosphorylation sites and an SH3 domain. Dai and Pendergast(1995) suggested that the ABI proteins may function to coordinate the cytoplasmic and nuclear functions of the ABL1 tyrosine kinase. Applications Tested/Suitable for anti-ABI2 antibody Western Blot (WB) Western Blot (WB) of anti-ABI2 antibody Anti-ABI2 antibody, MBS176106, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Human Placenta Tissue LysateLane 3: MCF-7 Cell LysateLane 4: HELA Cell LysateLane 5: JURKAT Cell Lysate TOP NCBI/Uniprot data below describe general gene information for ABI2. It may not necessarily be applicable to this product. NCBI GI # 50400673 NCBI GeneID 10152 NCBI Accession # Q9NYB9.1 [Other Products] UniProt Primary Accession # Q9NYB9 [Other Products] UniProt Secondary Accession # Q13147; Q13249; Q13801; Q9BV70; B4DSN1[Other Products] UniProt Related Accession # Q9NYB9[Other Products] Molecular Weight 54,819 Da TOP NCBI Official Full Name Abl interactor 2 NCBI Official Synonym Full Names abl-interactor 2 NCBI Official Symbol ABI2 [Similar Products] NCBI Official Synonym Symbols ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB [Similar Products] NCBI Protein Information abl interactor 2; abelson interactor 2; abl binding protein 3; arg-binding protein 1; abl-interactor protein 2b; arg protein tyrosine kinase-binding protein; abl-interacting protein 1 (SH3-containing protein) UniProt Protein Name Abl interactor 2 UniProt Synonym Protein Names Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1 Protein Family Abl interactor UniProt Gene Name ABI2 [Similar Products] UniProt Synonym Gene Names ARGBPIA; Abi-2; AblBP3; ArgBP1 [Similar Products] UniProt Entry Name ABI2_HUMAN TOP TOP UniProt Comments for ABI2 Abi-2: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. Belongs to the ABI family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffold; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 2q33Cellular Component: cytoskeleton; lamellipodium; cytoplasm; cytosol; filopodiumMolecular Function: protein binding; DNA binding; ubiquitin protein ligase binding; protein complex binding; Rac GTPase binding; cytoskeletal adaptor activity; kinase binding; SH3 domain bindingBiological Process: cell migration; peptidyl-tyrosine phosphorylation; actin polymerization and/or depolymerization; Rac protein signal transduction; cytoskeleton organization and biogenesis; cell motility Research Articles on ABI2 1. Abl-interactor 2 (ABI2) is a novel MLL translocation partner in acute myeloid leukemia. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. 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TOP Products associated with anti-ABI2 antibody Reference Product PubMed Publications TRIM32 antibody >2 publications with ABI2 and TRIM32 ABL1 antibody >1 publications with ABI2 and ABL1 WASF1 antibody >1 publications with ABI2 and WASF1 Pathways associated with anti-ABI2 antibody Products by Pathway Pathway Diagram Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram Immune System Pathway antibodies Immune System Pathway Diagram Innate Immune System Pathway antibodies Innate Immune System Pathway Diagram RAC1 Signaling Pathway antibodies RAC1 Signaling Pathway Diagram Regulation Of Actin Cytoskeleton Pathway antibodies Regulation Of Actin Cytoskeleton Pathway Diagram Regulation Of Actin Cytoskeleton Pathway antibodies Regulation Of Actin Cytoskeleton Pathway Diagram Regulation Of Actin Cytoskeleton Pathway antibodies Regulation Of Actin Cytoskeleton Pathway Diagram Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway antibodies Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway Diagram Signal Transduction Pathway antibodies Signal Transduction Pathway Diagram Signaling By VEGF Pathway antibodies Signaling By VEGF Pathway Diagram Diseases associated with anti-ABI2 antibody Disease Name Pubmed Publications Nervous System Diseases Antibodies >4 publications with ABI2 and Nervous System Diseases Cell Transformation, Neoplastic Antibodies >3 publications with ABI2 and Cell Transformation, Neoplastic Neurobehavioral Manifestations Antibodies >2 publications with ABI2 and Neurobehavioral Manifestations Necrosis Antibodies >2 publications with ABI2 and Necrosis Neoplasm Metastasis Antibodies >1 publications with ABI2 and Neoplasm Metastasis Neoplasms, Experimental Antibodies >1 publications with ABI2 and Neoplasms, Experimental Brain Diseases Antibodies >1 publications with ABI2 and Brain Diseases Blood Coagulation Disorders Antibodies >1 publications with ABI2 and Blood Coagulation Disorders Weight Loss Antibodies >1 publications with ABI2 and Weight Loss Learning Disorders Antibodies >1 publications with ABI2 and Learning Disorders Organs/Tissues associated with anti-ABI2 antibody Organ/Tissue Name Pubmed Publications Brain Antibodies >17 publications with ABI2 and Brain Vascular Antibodies >10 publications with ABI2 and Vascular Thyroid Antibodies >9 publications with ABI2 and Thyroid Blood Antibodies >6 publications with ABI2 and Blood Heart Antibodies >4 publications with ABI2 and Heart Muscle Antibodies >3 publications with ABI2 and Muscle Embryonic Tissue Antibodies >3 publications with ABI2 and Embryonic Tissue Eye Antibodies >2 publications with ABI2 and Eye Nerve Antibodies >2 publications with ABI2 and Nerve Bone Antibodies >2 publications with ABI2 and Bone TOP © 2006-24 MyBioSource.com. 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