Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ABL1 rightarrow Polyclonal ABL1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • WDR61 Antibody
 • Tryptophanyl-tRNA synthetase (WARS) ELISA Kit
 • a2-Macroglobulin Antibody
 • PSA Antibody
 • nucleotide-binding oligomerization domain containing 2 (NOD2... ELISA Kit
 • splicing factor proline-glutamine-rich (SFPQ) Antibody
 • Growth Hormone Binding Protein (GHBP) ELISA Kit
 • HIVEP2 - MIBP1 Peptide
 • Hemoglobin subunit alpha-1-2 (Hba1) Recombinant Protein
 • 1,5-Anhydroglucitol (1,5-AG) ELISA Kit
 • albumin Antibody
 • LAR-PTPRF - N Terminal GST Tag Enzyme
 • Cancer-testis antigen 1 (CTAG1A) ELISA Kit
 • USP21 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ABL1 antibody :: Rabbit ABL1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540930 anti-ABL1 antibody
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABL1, Polyclonal Antibody

 Also Known As   

ABL1 Antibody

 Product Synonym Names    Abelson murine leukemia viral oncogene homolog 1 antibodyAbelson tyrosine protein kinase 1 antibodyAbl 1 antibodyABL antibodyABL proto oncogene 1 non receptor tyrosine kinase antibodyABL1 antibody bcr/abl antibodyc abl oncogene 1 receptor tyrosine kinase antibodyJTK7 antibodyp150 antibodyProto oncogene tyrosine protein kinase ABL1 antibodyProto-oncogene c-Abl antibodyTyrosine-protein kinase ABL1 antibodyv abl Abelson murine leukemia viral oncogene homolog 1 antibodyv abl antibody
 Product Gene Name   

anti-ABL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
 Antibody/Peptide Pairs    ABL1 peptide (MBS542307) is used for blocking the activity of ABL1 antibody (MBS540930)
 Matching Pairs    Antibody: ABL1 (MBS540930)
Positive Control: ABL1 (MBS542500)
Table BarTOPTable Bar
 OMIM    189980
 3D Structure    ModBase 3D Structure for P00519
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Form/Format    Affinity Purified
 Concentration    0.5 ug/ul in antibody stabilization buffer (lot specific)
Section Bar
 Immunogen    Synthetic peptide taken within amino acid region 990-1130 of human Isoform IB of Tyorsine-protein kinase ABL1 protein.
 Immunoglobulin    IgG
 Expression    Widely expressed.
 Molecular Function    Kinase, Transferase, Tyrosine-protein kinase
 Structure    Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. Contains 1 proteins kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.
 Subcellular Location    Cytoplasm ; cytoskeleton, Nucleus, Mitochondrion
Section Bar
 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-ABL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-ABL1 antibody

   Affinity Purified Tyrosine-protein kinase ABL1 Antibody
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration.
 Product Categories/Family for anti-ABL1 antibody    Primary Antibodies; Protein Kinases; Tyrosine Kinases; ABL1 Antibody
 Applications Tested/Suitable for anti-ABL1 antibody   

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-ABL1 antibody    ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ABL1. It may not necessarily be applicable to this product.
 NCBI GI #    85681908
 NCBI GeneID    25
 NCBI Accession #    P00519.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P00519 [Other Products]
 UniProt Secondary Accession #    Q13869; Q13870; Q16133; Q17R61; Q45F09; A3KFJ3 [Other Products]
 UniProt Related Accession #    P00519 [Other Products]
 Molecular Weight    124,955 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Tyrosine-protein kinase ABL1
 NCBI Official Synonym Full Names    ABL proto-oncogene 1, non-receptor tyrosine kinase
 NCBI Official Symbol    ABL1 [Similar Products]
 NCBI Official Synonym Symbols   
ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase ABL1
 UniProt Protein Name    Tyrosine-protein kinase ABL1
 UniProt Synonym Protein Names   
Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    ABL1 [Similar Products]
 UniProt Synonym Gene Names    ABL; JTK7 [Similar Products]
 UniProt Entry Name    ABL1_HUMAN
Section Bar
 NCBI Summary for ABL1    This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Section Bar
 UniProt Comments for ABL1    Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
Table BarTOPTable Bar
 Research Articles on ABL1    1. Our results link FGF8, c-Abl and p300 in a regulatory pathway that controls DeltaNp63alpha protein stability and transcriptional activity.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products related to ABL1 Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS857515  Abl1 (Phospho-Tyr412) Antibody  MBS9204585  ABL1 Antibody (Center)
 MBS9209040  Phospho-ABL1 (Y251) Antibody  MBS8238280  Anti-ABL1 Antibody
 MBS8242355  Anti-ABL1 Antibody  MBS856768  ABL1/2 (phospho-Tyr393/429) Antibody
 MBS715728  Rabbit anti-human Tyrosine-protein kinase ABL1 polyclonal Antibody, Biotin conjugated  MBS7215575  Rat CDK5 and ABL1 enzyme subste 1 (CABLES1) ELISA Kit
 MBS7202863  Goat CDK5 and ABL1 enzyme subste 2 (CABLES2) ELISA Kit  MBS820417  Anti-ABL1/2 Antibody
Products associated with anti-ABL1 antibodyPathways associated with anti-ABL1 antibody
 Reference Product  PubMed Publications
 BCR antibody  >1293 publications with ABL1 and BCR
 CRKL antibody  >13 publications with ABL1 and CRKL
 RB1 antibody  >10 publications with ABL1 and RB1
 GRB2 antibody  >9 publications with ABL1 and GRB2
 CBL antibody  >9 publications with ABL1 and CBL
 ABI1 antibody  >9 publications with ABL1 and ABI1
 ATM antibody  >7 publications with ABL1 and ATM
 RAD51 antibody  >2 publications with ABL1 and RAD51
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-ABL1 antibodyOrgans/Tissues associated with anti-ABL1 antibody
 Disease Name  Pubmed Publications
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >571 publications with ABL1 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >215 publications with ABL1 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Cell Transformation, Neoplastic Antibodies  >81 publications with ABL1 and Cell Transformation, Neoplastic
 Carcinogenesis Antibodies  >80 publications with ABL1 and Carcinogenesis
 Anemia Antibodies  >27 publications with ABL1 and Anemia
 Cardiovascular Diseases Antibodies  >20 publications with ABL1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >20 publications with ABL1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >17 publications with ABL1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >14 publications with ABL1 and Nervous System Diseases
 Adenocarcinoma Antibodies  >13 publications with ABL1 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >363 publications with ABL1 and Blood
 Bone Antibodies  >222 publications with ABL1 and Bone
 Bone Marrow Antibodies  >213 publications with ABL1 and Bone Marrow
 Spleen Antibodies  >20 publications with ABL1 and Spleen
 Lung Antibodies  >18 publications with ABL1 and Lung
 Liver Antibodies  >12 publications with ABL1 and Liver
 Prostate Antibodies  >12 publications with ABL1 and Prostate
 Lymph Antibodies  >11 publications with ABL1 and Lymph
 Lymph Node Antibodies  >11 publications with ABL1 and Lymph Node
 Brain Antibodies  >11 publications with ABL1 and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions