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anti-ACADM antibody :: Goat ACADM Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420143
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACADM, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-ACADM Antibody

 Product Synonym Names    Goat Anti-ACADM, Biotinylated Antibody; ACADM; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; RP4-682C21.1; ACAD1; MCAD; MCADH; medium-chain acyl-CoA dehydrogenase; FLJ18227; FLJ93013; FLJ99884; medium-chain specific acyl-CoA dehydrogenase; ACADM antibody; acyl-Coenzyme A dehydrogenase; C-4 to C-12 straight chain antibody; RP4-682C21.1 antibody; ACAD1 antibody; MCAD antibody; MCADH antibody; medium-chain acyl-CoA dehydrogenase antibody; FLJ18227 antibody; FLJ93013 antibody; FLJ99884 antibody; medium-chain specific acyl-CoA dehydrogenase antibody
 Product Gene Name   

anti-ACADM antibody

[Similar Products]
 Antibody/Peptide Pairs    ACADM peptide (MBS426384) is used for blocking the activity of ACADM antibody (MBS420143)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RLIVAREHID KYKN
 OMIM    201450
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RLIVAREHIDKYKN, from the C Terminus of the protein sequence according to NP_000007.1; NP_001120800.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise both reported isoforms (NP_000007.1; NP_001120800.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ACADM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ACADM antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ACADM antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Liver shows mitochondrial staining in hepatocytes. Recommended concentration, 3-5ug/ml.
Western Blot: Approx 45kDa band observed in Human Kidney and Heart lysates (calculated MW of 46.6kDa according to NP_000007.1). Recommended for use at 0. 01-0.1ug/ml.
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 Western Blot (WB) of anti-ACADM antibody    Staining (0. 05ug/ml) of Human Heart lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-ACADM antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ACADM antibody    (3.8ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-ACADM antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ACADM. It may not necessarily be applicable to this product.
 NCBI GI #    4557231
 NCBI GeneID    34
 NCBI Accession #    NP_000007.1 [Other Products]
 NCBI Related Accession #    NP_001120800.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000016.5 [Other Products]
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 UniProt Secondary Accession #    Q5T4U4; Q9NYF1 [Other Products]
 UniProt Related Accession #    P11310 [Other Products]
 Molecular Weight    47,020 Da
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 NCBI Official Full Name    medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a
 NCBI Official Synonym Full Names    acyl-CoA dehydrogenase, C-4 to C-12 straight chain
 NCBI Official Symbol    ACADM [Similar Products]
 NCBI Official Synonym Symbols   
MCAD; ACAD1; MCADH
[Similar Products]
 NCBI Protein Information    medium-chain specific acyl-CoA dehydrogenase, mitochondrial
 UniProt Protein Name    Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
 Protein Family    Medium-chain specific acyl-CoA dehydrogenase
 UniProt Gene Name    ACADM [Similar Products]
 UniProt Synonym Gene Names    MCAD [Similar Products]
 UniProt Entry Name    ACADM_HUMAN
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 NCBI Summary for ACADM    This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACADM    ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; EC 1.3.8.7; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: axon; mitochondrial matrix; mitochondrion; nucleus; peroxisome

Molecular Function: acyl-CoA binding; acyl-CoA dehydrogenase activity; electron carrier activity; FAD binding; identical protein binding

Biological Process: carnitine biosynthetic process; carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis; medium-chain fatty acid catabolic process; medium-chain fatty acid metabolic process

Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of
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 Research Articles on ACADM    1. our study demonstrates that not all mutations identified in children with abnormal NBS profiles suggestive of MCAD deficiency result in a total loss in MCAD activity and function
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACADM antibodyPathways associated with anti-ACADM antibody
 Reference Product  PubMed Publications
 EHHADH antibody  >3 publications with ACADM and EHHADH
 ACAA2 antibody  >2 publications with ACADM and ACAA2
 ACAA1 antibody  >1 publications with ACADM and ACAA1
 ECHS1 antibody  >1 publications with ACADM and ECHS1
 HADHB antibody  >1 publications with ACADM and HADHB
 HADHA antibody  >1 publications with ACADM and HADHA
 Products by Pathway  Pathway Diagram
 Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway antibodies  Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway Diagram
 Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway antibodies  Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
Diseases associated with anti-ACADM antibodyOrgans/Tissues associated with anti-ACADM antibody
 Disease Name  Pubmed Publications
 Medium chain acyl CoA dehydrogenase deficiency Antibodies  >27 publications with ACADM and Medium chain acyl CoA dehydrogenase deficiency
 Fatty Liver Antibodies  >14 publications with ACADM and Fatty Liver
 Liver Diseases Antibodies  >7 publications with ACADM and Liver Diseases
 Cardiovascular Diseases Antibodies  >6 publications with ACADM and Cardiovascular Diseases
 Obesity Antibodies  >5 publications with ACADM and Obesity
 Inflammation Antibodies  >4 publications with ACADM and Inflammation
 Insulin Resistance Antibodies  >4 publications with ACADM and Insulin Resistance
 Heart Diseases Antibodies  >4 publications with ACADM and Heart Diseases
 Hepatomegaly Antibodies  >3 publications with ACADM and Hepatomegaly
 Necrosis Antibodies  >2 publications with ACADM and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with ACADM and Blood
 Liver Antibodies  >16 publications with ACADM and Liver
 Muscle Antibodies  >8 publications with ACADM and Muscle
 Heart Antibodies  >7 publications with ACADM and Heart
 Adipose Tissue Antibodies  >5 publications with ACADM and Adipose Tissue
 Connective Tissue Antibodies  >4 publications with ACADM and Connective Tissue
 Kidney Antibodies  >3 publications with ACADM and Kidney
 Thyroid Antibodies  >2 publications with ACADM and Thyroid
 Vascular Antibodies  >2 publications with ACADM and Vascular
 Placenta Antibodies  >2 publications with ACADM and Placenta
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