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anti-ACAP1 antibody :: Rabbit anti-Human ACAP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9406173
Unit / Price
0.1 mL  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACAP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

ACAP1 antibody

 Product Gene Name   

anti-ACAP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607763
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Purified by antigen-affinity chromatography.
 Form/Format    Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
 Concentration    1 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthetic peptide contain a sequence corresponding to a region within amino acids 678 and 740 of Human CENTB1
 Target Name    ACAP1
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 Preparation and Storage    Store at -20C for long term preservation (recommended). Store at 4C for short term use.
 Other Notes    Small volumes of anti-ACAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ACAP1 antibody    Total protein Ab
 Applications Tested/Suitable for anti-ACAP1 antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-ACAP1 antibody    Western blotting: 1:500-1:3000
Immunofluorescence: 1:100-1:200
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 Testing Data of anti-ACAP1 antibody    Sample (30 ug of whole cell lysate) A: Raji 7.5% SDS PAGE Primary antibody diluted at 1: 1000
anti-ACAP1 antibody Testing Data image
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 Immunofluorescence (IF) of anti-ACAP1 antibody    Immunofluorescence analysis of methanol-fixed H1299, using Centaurin beta 1 antibody at 1: 500 dilution.
anti-ACAP1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ACAP1. It may not necessarily be applicable to this product.
 NCBI GI #    7661880
 NCBI GeneID    9744
 NCBI Accession #    NP_055531 [Other Products]
 NCBI GenBank Nucleotide #    NM_014716.3 [Other Products]
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 UniProt Secondary Accession #    Q53XN9 [Other Products]
 UniProt Related Accession #    Q15027 [Other Products]
 Molecular Weight    Predicted: 82kd
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 NCBI Official Full Name    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
 NCBI Official Synonym Full Names    ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
 NCBI Official Symbol    ACAP1 [Similar Products]
 NCBI Official Synonym Symbols   
CENTB1
[Similar Products]
 NCBI Protein Information    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
 UniProt Protein Name    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
 UniProt Synonym Protein Names   
Centaurin-beta-1; Cnt-b1
 Protein Family    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
 UniProt Gene Name    ACAP1 [Similar Products]
 UniProt Synonym Gene Names    CENTB1; KIAA0050; Cnt-b1 [Similar Products]
 UniProt Entry Name    ACAP1_HUMAN
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 UniProt Comments for ACAP1    CENTB1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol.

Protein type: GAPs; GAPs, ARF; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; recycling endosome membrane

Molecular Function: zinc ion binding

Biological Process: protein transport; positive regulation of GTPase activity
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 Research Articles on ACAP1    1. ACAP1 and ARAP2 each colocalize with Arf6 but they did not colocalize with each other and have opposing effects on focal adhesions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACAP1 antibodyPathways associated with anti-ACAP1 antibody
 Reference Product  PubMed Publications
 ARF6 antibody  >14 publications with ACAP1 and ARF6
 ARF5 antibody  >1 publications with ACAP1 and ARF5
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram
Diseases associated with anti-ACAP1 antibodyOrgans/Tissues associated with anti-ACAP1 antibody
 Disease Name  Pubmed Publications
 Bacterial Infections Antibodies  >1 publications with ACAP1 and Bacterial Infections
 Disease Models, Animal Antibodies  >1 publications with ACAP1 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with ACAP1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with ACAP1 and Brain
 Lung Antibodies  >2 publications with ACAP1 and Lung
 Nerve Antibodies  >1 publications with ACAP1 and Nerve
 Intestine Antibodies  >1 publications with ACAP1 and Intestine
 Muscle Antibodies  >1 publications with ACAP1 and Muscle
 Heart Antibodies  >1 publications with ACAP1 and Heart
 Vascular Antibodies  >1 publications with ACAP1 and Vascular
 Blood Antibodies  >1 publications with ACAP1 and Blood
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