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anti-ACAT1 antibody :: Rabbit anti-Human ACAT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246787
Unit / Price
0.2 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACAT1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human ACAT1

 Product Synonym Names    Anti-ACAT1 Antibody (C-Terminus) IHC-plus; ACAT1; ACAT; Acetoacetyl-CoA thiolase; Acetyl-CoA acetyltransferase 1; MAT; T2; THIL; Human ACAT1
 Product Gene Name   

anti-ACAT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 607809
 3D Structure    ModBase 3D Structure for P24752
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Ammonium sulfate precipitation
 Form/Format    PBS, 0.09% sodium azide
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 Target Species    Human
 Immunogen Description    KLH conjugated synthetic peptide selected from the C-terminal region of human ACAT1.
 Immunogen Type    Synthetic peptide
 Immunogen    ACAT1 antibody was raised against kLH conjugated synthetic peptide selected from the C-terminal region of human ACAT1.
 Antigen Modification    C-Terminus
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
 Other Notes    Small volumes of anti-ACAT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACAT1 antibody

   The ACAT1 mRNA encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. The ACAT gene spans approximately 27 kb and contains 12 exons interrupted by 11 introns. Defects in this gene are associated with the alpha-methylacetoaceticaciduria disorder, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.
 Applications Tested/Suitable for anti-ACAT1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-ACAT1 antibody    IHC-P (10 ug/ml), WB (1:1000)
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 Immunohistochemistry (IHC) of anti-ACAT1 antibody    Anti-ACAT1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-ACAT1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ACAT1 antibody    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ACAT1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-ACAT1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ACAT1 antibody    Western blot of anti-ACAT1 Pab in SK-BR-3 cell line lysates (35 ug/lane). ACAT1 (arrow) was detected using the purified Pab (1:60 dilution).
anti-ACAT1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACAT1. It may not necessarily be applicable to this product.
 NCBI GI #    4557237
 NCBI GeneID    38
 NCBI Accession #    NP_000010.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000019.3 [Other Products]
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 UniProt Primary Accession #    P24752 [Other Products]
 UniProt Secondary Accession #    Q96FG8; B2R6H1; G3XAB4 [Other Products]
 UniProt Related Accession #    P24752 [Other Products]
 Molecular Weight    17,175 Da
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 NCBI Official Full Name    acetyl-CoA acetyltransferase, mitochondrial
 NCBI Official Synonym Full Names    acetyl-CoA acetyltransferase 1
 NCBI Official Symbol    ACAT1 [Similar Products]
 NCBI Official Synonym Symbols   
T2; MAT; ACAT; THIL
[Similar Products]
 NCBI Protein Information    acetyl-CoA acetyltransferase, mitochondrial; acetoacetyl-CoA thiolase; acetoacetyl Coenzyme A thiolase; acetyl-Coenzyme A acetyltransferase 1; mitochondrial acetoacetyl-CoA thiolase
 UniProt Protein Name    Acetyl-CoA acetyltransferase, mitochondrial
 UniProt Synonym Protein Names   
Acetoacetyl-CoA thiolase; T2
 UniProt Gene Name    ACAT1 [Similar Products]
 UniProt Synonym Gene Names    ACAT; MAT [Similar Products]
 UniProt Entry Name    THIL_HUMAN
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 NCBI Summary for ACAT1    This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009]
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 UniProt Comments for ACAT1    ACAT1: Plays a major role in ketone body metabolism. Defects in ACAT1 are a cause of 3-ketothiolase deficiency (3KTD); also known as alpha- methylacetoaceticaciduria. 3KTD is an inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded. Urinary excretion of 2-methyl-3- hydroxybutyric acid, 2-methylacetoacetic acid, triglylglycine, butanone is increased. It seems likely that the severity of this disease correlates better with the environmental or acquired factors than with the ACAT1 genotype. Belongs to the thiolase family.

Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Acetyltransferase; Lipid Metabolism - synthesis and degradation of ketone bodies; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - tryptophan; Mitochondrial; Amino Acid Metabolism - lysine degradation; EC 2.3.1.9; Carbohydrate Metabolism - propanoate

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane

Molecular Function: protein homodimerization activity; enzyme binding; acetyl-CoA C-acetyltransferase activity; metal ion binding; coenzyme binding

Biological Process: response to starvation; ketone body catabolic process; response to hormone stimulus; ketone body biosynthetic process; branched chain family amino acid catabolic process; cellular lipid metabolic process; ketone body metabolic process; brain development; liver development; response to organic cyclic substance; protein homooligomerization

Disease: Alpha-methylacetoacetic Aciduria
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 Research Articles on ACAT1    1. Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity ACAT1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACAT1 antibodyPathways associated with anti-ACAT1 antibody
 Reference Product  PubMed Publications
 HMGCS2 antibody  >6 publications with ACAT1 and HMGCS2
 OXCT1 antibody  >5 publications with ACAT1 and OXCT1
 EHHADH antibody  >2 publications with ACAT1 and EHHADH
 ACADSB antibody  >1 publications with ACAT1 and ACADSB
 ACADS antibody  >1 publications with ACAT1 and ACADS
 Products by Pathway  Pathway Diagram
 Branched-chain Amino Acid Catabolism Pathway antibodies  Branched-chain Amino Acid Catabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
Diseases associated with anti-ACAT1 antibodyOrgans/Tissues associated with anti-ACAT1 antibody
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >76 publications with ACAT1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >51 publications with ACAT1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >15 publications with ACAT1 and Nervous System Diseases
 Dyslipidemias Antibodies  >15 publications with ACAT1 and Dyslipidemias
 Fatty Liver Antibodies  >14 publications with ACAT1 and Fatty Liver
 Hyperlipidemias Antibodies  >14 publications with ACAT1 and Hyperlipidemias
 Liver Diseases Antibodies  >11 publications with ACAT1 and Liver Diseases
 Hypertension Antibodies  >10 publications with ACAT1 and Hypertension
 Necrosis Antibodies  >9 publications with ACAT1 and Necrosis
 Inflammation Antibodies  >8 publications with ACAT1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with ACAT1 and Blood
 Liver Antibodies  >48 publications with ACAT1 and Liver
 Intestine Antibodies  >22 publications with ACAT1 and Intestine
 Brain Antibodies  >13 publications with ACAT1 and Brain
 Muscle Antibodies  >12 publications with ACAT1 and Muscle
 Bone Antibodies  >10 publications with ACAT1 and Bone
 Ovary Antibodies  >7 publications with ACAT1 and Ovary
 Heart Antibodies  >7 publications with ACAT1 and Heart
 Kidney Antibodies  >6 publications with ACAT1 and Kidney
 Adipose Tissue Antibodies  >5 publications with ACAT1 and Adipose Tissue
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