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anti-ACE2 antibody :: Rabbit anti-Human ACE2 / ACE-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243413
Unit / Price
0.2 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACE2 / ACE-2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human ACE2 / ACE-2

 Product Synonym Names    Anti-ACE2 / ACE-2 Antibody (Internal) IHC-plus; ACE2; ACE-related carboxypeptidase; ACEH; Metalloprotease MPROT15; Human ACE2; ACE-2
 Product Gene Name   

anti-ACE2 antibody

[Similar Products]
 Product Synonym Gene Name    ACE-2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300335
 3D Structure    ModBase 3D Structure for Q9BYF1
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Ammonium sulfate precipitation
 Form/Format    PBS, 0.09% sodium azide
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 Target Species    Human
 Immunogen Description    KLH conjugated synthetic peptide selected from the center region of human ACE2.
 Immunogen Type    Synthetic peptide
 Immunogen    ACE2 / ACE-2 antibody was raised against kLH conjugated synthetic peptide selected from the center region of human ACE2. (SARS Receptor)
 Antigen Modification    Internal
 Epitope    aa140-172
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
 Other Notes    Small volumes of anti-ACE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACE2 antibody

   Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII.
 Product Categories/Family for anti-ACE2 antibody    Family: Protease
Subfamily: Metallopeptidase M2
 Applications Tested/Suitable for anti-ACE2 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-ACE2 antibody    Flo (1:10 - 1:50), IHC-P (5 ug/ml), WB (1:1000)
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 Immunohistochemistry (IHC) of anti-ACE2 antibody    Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACE2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ACE2 antibody    Anti-ACE-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACE2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ACE2 antibody    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
anti-ACE2 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-ACE2 antibody    Flow cytometry of HL-60 cells using ACE2 (SARS Receptor) Antibody (Center) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ACE2 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Western Blot (WB) of anti-ACE2 antibody    Western blot of anti-ACE2 (SARS Receptor) Antibody (Center) in HL60 cell line lysates (35 ug/lane). ACE2 (arrow) was detected using the purified Pab.
anti-ACE2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACE2. It may not necessarily be applicable to this product.
 NCBI GI #    11225609
 NCBI GeneID    59272
 NCBI Accession #    NP_068576.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021804.2 [Other Products]
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 UniProt Primary Accession #    Q9BYF1 [Other Products]
 UniProt Secondary Accession #    Q6UWP0; Q86WT0; Q9NRA7; Q9UFZ6; C7ECU1 [Other Products]
 UniProt Related Accession #    Q9BYF1 [Other Products]
 Molecular Weight    63,912 Da
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 NCBI Official Full Name    angiotensin-converting enzyme 2
 NCBI Official Synonym Full Names    angiotensin I converting enzyme 2
 NCBI Official Symbol    ACE2 [Similar Products]
 NCBI Official Synonym Symbols   
ACEH
[Similar Products]
 NCBI Protein Information    angiotensin-converting enzyme 2; peptidyl-dipeptidase A; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin-converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
 UniProt Protein Name    Angiotensin-converting enzyme 2
 UniProt Synonym Protein Names   
ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15Processed angiotensin-converting enzyme 2
 Protein Family    Angiotensin-converting enzyme
 UniProt Gene Name    ACE2 [Similar Products]
 UniProt Synonym Gene Names    ACEH [Similar Products]
 UniProt Entry Name    ACE2_HUMAN
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 NCBI Summary for ACE2    The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACE2    ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.17.23; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: extracellular space; cell surface; cytoplasm; plasma membrane; integral to membrane; extracellular region; lipid raft

Molecular Function: viral receptor activity; peptidyl-dipeptidase activity; protein binding; metallopeptidase activity; zinc ion binding; carboxypeptidase activity; peptide hormone binding; endopeptidase activity; glycoprotein binding

Biological Process: virion attachment, binding of host cell surface receptor; entry of virus into host cell; maternal process involved in pregnancy; regulation of vasodilation; angiotensin maturation; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of cytokine production; regulation of cell proliferation; cellular protein metabolic process; regulation of vasoconstriction; regulation of inflammatory response; angiotensin catabolic process in blood; receptor biosynthetic process; angiotensin mediated drinking behavior
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 Research Articles on ACE2    1. ACE2 cleavage is regulated by influenza A H1N1 neuraminidase.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACE2 antibodyPathways associated with anti-ACE2 antibody
 Reference Product  PubMed Publications
 ACE antibody  >489 publications with ACE2 and ACE
 AGT antibody  >27 publications with ACE2 and AGT
 SLC6A19 antibody  >9 publications with ACE2 and SLC6A19
 ATP6AP2 antibody  >9 publications with ACE2 and ATP6AP2
 CMA1 antibody  >1 publications with ACE2 and CMA1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with anti-ACE2 antibodyOrgans/Tissues associated with anti-ACE2 antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >324 publications with ACE2 and Hypertension
 Vascular Diseases Antibodies  >236 publications with ACE2 and Vascular Diseases
 Heart Diseases Antibodies  >160 publications with ACE2 and Heart Diseases
 Kidney Diseases Antibodies  >114 publications with ACE2 and Kidney Diseases
 Hypertrophy Antibodies  >90 publications with ACE2 and Hypertrophy
 Fibrosis Antibodies  >90 publications with ACE2 and Fibrosis
 Hypertension, Renal Antibodies  >87 publications with ACE2 and Hypertension, Renal
 Heart Failure Antibodies  >83 publications with ACE2 and Heart Failure
 Inflammation Antibodies  >72 publications with ACE2 and Inflammation
 Ventricular Remodeling Antibodies  >43 publications with ACE2 and Ventricular Remodeling
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >259 publications with ACE2 and Kidney
 Muscle Antibodies  >154 publications with ACE2 and Muscle
 Brain Antibodies  >83 publications with ACE2 and Brain
 Intestine Antibodies  >20 publications with ACE2 and Intestine
 Placenta Antibodies  >15 publications with ACE2 and Placenta
 Testis Antibodies  >11 publications with ACE2 and Testis
 Mixed Antibodies  >8 publications with ACE2 and Mixed
 Eye Antibodies  >8 publications with ACE2 and Eye
 Stomach Antibodies  >4 publications with ACE2 and Stomach
 Mouth Antibodies  >1 publications with ACE2 and Mouth
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