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anti-ACE2 antibody :: Rabbit ACE2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221779
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACE2, Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN ACE2 (N-TERMINAL)

 Product Gene Name   

anti-ACE2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300335
 3D Structure    ModBase 3D Structure for Q9BYF1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    This item is specific for human Angiotensin-converting enzyme 2 (ACE2). ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system.

ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation.

A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.02% Sodium Azide
 Immunogen    Synthetic peptide corresponding to a sequence within the amino terminus of human ACE2.
Buffer Solution
 Antiserum Preparation    Antisera to human ACE2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-ACE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACE2 antibody

   MBS221779 is specific for human Angiotensin-converting enzyme 2 (ACE2). ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system. ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation. A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein.
 Applications Tested/Suitable for anti-ACE2 antibody   

Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-ACE2 antibody    Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
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 Testing Data #1 of anti-ACE2 antibody    Western blot analysis of human kidney lysate probed with Rabbit anti Human ACE2 (MBS221779)
anti-ACE2 antibody Testing Data #1 image
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 Testing Data #2 of anti-ACE2 antibody    Immunohistochemical staining of human kidney woth Rabbit anti Human ACE2 (MBS221779)
anti-ACE2 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for ACE2. It may not necessarily be applicable to this product.
 NCBI GI #    11225609
 NCBI GeneID    59272
 NCBI Accession #    NP_068576.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021804.2 [Other Products]
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 UniProt Primary Accession #    Q9BYF1 [Other Products]
 UniProt Secondary Accession #    Q6UWP0; Q86WT0; Q9NRA7; Q9UFZ6; C7ECU1 [Other Products]
 UniProt Related Accession #    Q9BYF1 [Other Products]
 Molecular Weight    63,912 Da
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 NCBI Official Full Name    angiotensin-converting enzyme 2
 NCBI Official Synonym Full Names    angiotensin I converting enzyme 2
 NCBI Official Symbol    ACE2 [Similar Products]
 NCBI Official Synonym Symbols   
ACEH
[Similar Products]
 NCBI Protein Information    angiotensin-converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme homolog; metalloprotease MPROT15
 UniProt Protein Name    Angiotensin-converting enzyme 2
 UniProt Synonym Protein Names   
ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15Processed angiotensin-converting enzyme 2
 Protein Family    Angiotensin-converting enzyme
 UniProt Gene Name    ACE2 [Similar Products]
 UniProt Synonym Gene Names    ACEH [Similar Products]
 UniProt Entry Name    ACE2_HUMAN
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 NCBI Summary for ACE2    The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACE2    ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.17.23; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: extracellular space; cell surface; cytoplasm; extracellular region; integral to membrane; plasma membrane; lipid raft

Molecular Function: viral receptor activity; peptidyl-dipeptidase activity; protein binding; zinc ion binding; metallopeptidase activity; carboxypeptidase activity; peptide hormone binding; endopeptidase activity; glycoprotein binding

Biological Process: virion attachment, binding of host cell surface receptor; entry of virus into host cell; maternal process involved in pregnancy; regulation of vasodilation; angiotensin maturation; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of cytokine production; regulation of cell proliferation; cellular protein metabolic process; regulation of vasoconstriction; regulation of inflammatory response; angiotensin catabolic process in blood; receptor biosynthetic process; angiotensin mediated drinking behavior
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 Research Articles on ACE2    1. These data demonstrate that MSCs modified to overexpress the ACE2 gene can produce biologically active ACE2 protein over a sustained period of time and have an enhanced ability to promote endothelial repair after LPS challenge
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACE2 antibodyPathways associated with anti-ACE2 antibody
 Reference Product  PubMed Publications
 ACE antibody  >502 publications with ACE2 and ACE
 AGT antibody  >29 publications with ACE2 and AGT
 SLC6A19 antibody  >9 publications with ACE2 and SLC6A19
 ATP6AP2 antibody  >9 publications with ACE2 and ATP6AP2
 CMA1 antibody  >1 publications with ACE2 and CMA1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with anti-ACE2 antibodyOrgans/Tissues associated with anti-ACE2 antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >326 publications with ACE2 and Hypertension
 Vascular Diseases Antibodies  >238 publications with ACE2 and Vascular Diseases
 Heart Diseases Antibodies  >161 publications with ACE2 and Heart Diseases
 Kidney Diseases Antibodies  >115 publications with ACE2 and Kidney Diseases
 Fibrosis Antibodies  >94 publications with ACE2 and Fibrosis
 Hypertrophy Antibodies  >92 publications with ACE2 and Hypertrophy
 Hypertension, Renal Antibodies  >88 publications with ACE2 and Hypertension, Renal
 Heart Failure Antibodies  >86 publications with ACE2 and Heart Failure
 Inflammation Antibodies  >76 publications with ACE2 and Inflammation
 Ventricular Remodeling Antibodies  >46 publications with ACE2 and Ventricular Remodeling
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >264 publications with ACE2 and Kidney
 Muscle Antibodies  >155 publications with ACE2 and Muscle
 Brain Antibodies  >87 publications with ACE2 and Brain
 Intestine Antibodies  >21 publications with ACE2 and Intestine
 Placenta Antibodies  >15 publications with ACE2 and Placenta
 Testis Antibodies  >11 publications with ACE2 and Testis
 Mixed Antibodies  >8 publications with ACE2 and Mixed
 Eye Antibodies  >8 publications with ACE2 and Eye
 Stomach Antibodies  >4 publications with ACE2 and Stomach
 Mouth Antibodies  >2 publications with ACE2 and Mouth
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