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anti-ACE2 antibody :: Rabbit anti-Human ACE2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS628626 anti-ACE2 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACE2, Polyclonal Antibody

 Also Known As   

ACE2, ID (Angiotensin-converting Enzyme 2, ACE-related Carboxypeptidase, Angiotensin-converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, Processed Angiotensin-converting Enzyme 2, UNQ868/PRO1885)

 Product Synonym Names    Anti -ACE2, ID (Angiotensin-converting Enzyme 2, ACE-related Carboxypeptidase, Angiotensin-converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, Processed Angiotensin-converting Enzyme 2, UNQ868/PRO1885)
 Product Gene Name   

anti-ACE2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (15579156..15620192, complement). Location: Xp22
 OMIM    300335
 3D Structure    ModBase 3D Structure for Q9BYF1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human ACE2.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the center region of human ACE2 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ACE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACE2 antibody

   ACE2 cDNA encodes a deduced 805aa protein containing a potential 17aa N-terminal signal peptide and a putative 22aa C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9aa. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus.
 Product Categories/Family for anti-ACE2 antibody    Antibodies; Abs to Enzymes, Angiotensin Converting (ACE)
 Applications Tested/Suitable for anti-ACE2 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

 Application Notes for anti-ACE2 antibody    Suitable for use in ELISA, Western Blot, Flow Cytometry, and Immunohistochemistry.
Dilution: Western Blot: 1:50-1:200
ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100
Flow Cytometry: 1:10-1:50
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NCBI/Uniprot data below describe general gene information for ACE2. It may not necessarily be applicable to this product.
 NCBI GI #    11225609
 NCBI GeneID    59272
 NCBI Accession #    NP_068576.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021804.2 [Other Products]
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 UniProt Primary Accession #    Q9BYF1 [Other Products]
 UniProt Secondary Accession #    Q6UWP0; Q86WT0; Q9NRA7; Q9UFZ6 [Other Products]
 UniProt Related Accession #    Q9BYF1 [Other Products]
 Molecular Weight    92,463 Da [Similar Products]
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 NCBI Official Full Name    angiotensin-converting enzyme 2
 NCBI Official Synonym Full Names    angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
 NCBI Official Symbol    ACE2 [Similar Products]
 NCBI Official Synonym Symbols   
ACEH; DKFZp434A014
[Similar Products]
 NCBI Protein Information    angiotensin-converting enzyme 2; OTTHUMP00000022963; metalloprotease MPROT15; ACE-related carboxypeptidase; angiotensin I converting enzyme 2; angiotensin-converting enzyme homolog
 UniProt Protein Name    Angiotensin-converting enzyme 2
 UniProt Synonym Protein Names   
ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15
 Protein Family    Angiotensin-converting enzyme
 UniProt Gene Name    ACE2 [Similar Products]
 UniProt Entry Name    ACE2_HUMAN
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 NCBI Summary for ACE2    The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq]
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 UniProt Comments for ACE2    ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.17.23; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: extracellular space; cell surface; cytoplasm; integral to membrane; plasma membrane; extracellular region; lipid raft

Molecular Function: viral receptor activity; peptidyl-dipeptidase activity; protein binding; zinc ion binding; carboxypeptidase activity; metallopeptidase activity; peptide hormone binding; endopeptidase activity; glycoprotein binding

Biological Process: virion attachment, binding of host cell surface receptor; entry of virus into host cell; maternal process involved in pregnancy; regulation of vasodilation; angiotensin maturation; proteolysis; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of cytokine production; regulation of cell proliferation; cellular protein metabolic process; regulation of vasoconstriction; regulation of inflammatory response; angiotensin catabolic process in blood; receptor biosynthetic process; angiotensin mediated drinking behavior
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 Research Articles on ACE2    1. These results suggest that the structural features of the hot spot on hACE2 were among the driving forces for the convergent evolution of NL63 and SARS coronaviruses.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACE2 antibodyPathways associated with anti-ACE2 antibody
 Reference Product  PubMed Publications
 AGT antibody  >15 publications with ACE2 and AGT
 NTS antibody  >3 publications with ACE2 and NTS
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with anti-ACE2 antibodyOrgans/Tissues associated with anti-ACE2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >187 publications with ACE2 and Cardiovascular Diseases
 Hypertension Antibodies  >183 publications with ACE2 and Hypertension
 Common Cold Antibodies  >65 publications with ACE2 and Common Cold
 Kidney Diseases Antibodies  >59 publications with ACE2 and Kidney Diseases
 Fibrosis Antibodies  >47 publications with ACE2 and Fibrosis
 Heart Failure Antibodies  >43 publications with ACE2 and Heart Failure
 Lung Diseases Antibodies  >30 publications with ACE2 and Lung Diseases
 Ventricular Remodeling Antibodies  >25 publications with ACE2 and Ventricular Remodeling
 Cardiomegaly Antibodies  >23 publications with ACE2 and Cardiomegaly
 Inflammation Antibodies  >21 publications with ACE2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >137 publications with ACE2 and Kidney
 Muscle Antibodies  >83 publications with ACE2 and Muscle
 Brain Antibodies  >40 publications with ACE2 and Brain
 Intestine Antibodies  >13 publications with ACE2 and Intestine
 Testis Antibodies  >10 publications with ACE2 and Testis
 Placenta Antibodies  >7 publications with ACE2 and Placenta
 Mixed Antibodies  >6 publications with ACE2 and Mixed
 Eye Antibodies  >4 publications with ACE2 and Eye
 Stomach Antibodies  >3 publications with ACE2 and Stomach
 Mouth Antibodies  >1 publications with ACE2 and Mouth
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