AAI40806.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
150,557 Da
NCBI Official Full Name
ACIN1 protein
NCBI Official Synonym Full Names
apoptotic chromatin condensation inducer 1
NCBI Protein Information
apoptotic chromatin condensation inducer in the nucleus; functional spliceosome-associated protein 152
UniProt Protein Name
Apoptotic chromatin condensation inducer in the nucleus
UniProt Synonym Gene Names
UniProt Entry Name
ACINU_HUMAN
NCBI Summary for ACIN1
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for ACIN1
acinus: an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described.
Protein type: Spliceosome; RNA splicing; RNA-binding; Apoptosis
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: nucleoplasm; cytoplasm; nucleolus; plasma membrane; nuclear speck; cytosol; nucleus
Molecular Function: protein binding; enzyme binding; nucleic acid binding; ATPase activity; nucleotide binding
Biological Process: positive regulation of monocyte differentiation; negative regulation of nuclear mRNA splicing, via spliceosome; apoptosis; positive regulation of apoptosis; RNA splicing; erythrocyte differentiation; mRNA processing; apoptotic chromosome condensation; cell structure disassembly during apoptosis
Research Articles on ACIN1
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Products associated with anti-ACIN1 antibody
Pathways associated with anti-ACIN1 antibody
Diseases associated with anti-ACIN1 antibody
Organs/Tissues associated with anti-ACIN1 antibody
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