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anti-TNK2 antibody :: Rabbit anti-Human ACK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6004672 anti-TNK2 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACK1 (TNK2), Polyclonal Antibody

 Also Known As   

ACK1, phosphorylated (Y826) (TNK2, ACK1, Activated CDC42 kinase 1, Tyrosine kinase non-receptor protein 2)

 Product Synonym Names    Anti -ACK1, phosphorylated (Y826) (TNK2, ACK1, Activated CDC42 kinase 1, Tyrosine kinase non-receptor protein 2)
 Product Gene Name   

anti-TNK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (195590235..195635880, complement). Location: 3q29
 OMIM    606994
 3D Structure    ModBase 3D Structure for Q07912
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    Phospho-ACK1-Y826 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 814~844 amino acids surrounding Y826 of human ACK1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-TNK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TNK2 antibody

   ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
 Product Categories/Family for anti-TNK2 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-TNK2 antibody   

ELISA (EL/EIA), Gel Shift Assay (GS/EMSA)

 Application Notes for anti-TNK2 antibody    Suitable for use in Dot Blot, ELISA
Dilution: ELISA: 1:1,000
Dot Blot 1:500
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NCBI/Uniprot data below describe general gene information for TNK2. It may not necessarily be applicable to this product.
 NCBI GI #    58331191
 NCBI GeneID    10188
 NCBI Accession #    NP_001010938.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001010938.1 [Other Products]
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 UniProt Primary Accession #    Q07912 [Other Products]
 UniProt Secondary Accession #    Q6ZMQ0; Q8N6U7; Q96H59 [Other Products]
 UniProt Related Accession #    Q07912 [Other Products]
 Molecular Weight    114,569 Da [Similar Products]
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 NCBI Official Full Name    activated CDC42 kinase 1 isoform 2
 NCBI Official Synonym Full Names    tyrosine kinase, non-receptor, 2
 NCBI Official Symbol    TNK2 [Similar Products]
 NCBI Official Synonym Symbols   
ACK; ACK1; ACK-1; p21cdc42Hs
[Similar Products]
 NCBI Protein Information    activated CDC42 kinase 1; activated p21cdc42Hs kinase; activated Cdc42-associated kinase 1; tyrosine kinase non-receptor protein 2
 UniProt Protein Name    Activated CDC42 kinase 1
 UniProt Synonym Protein Names   
Tyrosine kinase non-receptor protein 2
 Protein Family    Activated CDC42 kinase
 UniProt Gene Name    TNK2 [Similar Products]
 UniProt Synonym Gene Names    ACK1; ACK-1 [Similar Products]
 UniProt Entry Name    ACK1_HUMAN
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 NCBI Summary for TNK2    This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNK2    Ack: a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; EC 2.7.11.1; TK group; Ack family

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: cytoplasmic vesicle membrane; clathrin-coated vesicle; dendrite; coated pit; extrinsic to internal side of plasma membrane; growth cone; adherens junction; cell soma; membrane; axon; cytoplasm; plasma membrane; nucleus; endosome

Molecular Function: protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; metal ion binding; WW domain binding; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; ATP binding; GTPase inhibitor activity; epidermal growth factor receptor binding; hormone receptor binding

Biological Process: cell migration; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; small GTPase mediated signal transduction; negative regulation of catalytic activity; innate immune response; endocytosis; cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
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 Research Articles on TNK2    1. ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNK2 antibodyPathways associated with anti-TNK2 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >38 publications with TNK2 and CDC42
 EGFR antibody  >12 publications with TNK2 and EGFR
 SRC antibody  >11 publications with TNK2 and SRC
 WWOX antibody  >3 publications with TNK2 and WWOX
 BCAR1 antibody  >3 publications with TNK2 and BCAR1
 GRB2 antibody  >3 publications with TNK2 and GRB2
 SNX9 antibody  >1 publications with TNK2 and SNX9
 HSH2D antibody  >1 publications with TNK2 and HSH2D
 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
Diseases associated with anti-TNK2 antibodyOrgans/Tissues associated with anti-TNK2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >25 publications with TNK2 and Neoplasms
 Genital Diseases, Male Antibodies  >6 publications with TNK2 and Genital Diseases, Male
 Cell Transformation, Neoplastic Antibodies  >4 publications with TNK2 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >4 publications with TNK2 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >2 publications with TNK2 and Cardiovascular Diseases
 Hyperplasia Antibodies  >2 publications with TNK2 and Hyperplasia
 Kidney Diseases Antibodies  >2 publications with TNK2 and Kidney Diseases
 Hypertrophy Antibodies  >2 publications with TNK2 and Hypertrophy
 Hypertension Antibodies  >1 publications with TNK2 and Hypertension
 Neoplasms, Experimental Antibodies  >1 publications with TNK2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >9 publications with TNK2 and Prostate
 Kidney Antibodies  >5 publications with TNK2 and Kidney
 Brain Antibodies  >5 publications with TNK2 and Brain
 Nerve Antibodies  >3 publications with TNK2 and Nerve
 Lymph Antibodies  >2 publications with TNK2 and Lymph
 Lung Antibodies  >2 publications with TNK2 and Lung
 Lymph Node Antibodies  >2 publications with TNK2 and Lymph Node
 Blood Antibodies  >2 publications with TNK2 and Blood
 Stomach Antibodies  >1 publications with TNK2 and Stomach
 Esophagus Antibodies  >1 publications with TNK2 and Esophagus
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