NP_001010938.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,349 Da
NCBI Official Full Name
activated CDC42 kinase 1 isoform 2
NCBI Official Synonym Full Names
tyrosine kinase, non-receptor, 2
NCBI Protein Information
activated CDC42 kinase 1
UniProt Protein Name
Activated CDC42 kinase 1
UniProt Synonym Protein Names
Tyrosine kinase non-receptor protein 2
UniProt Synonym Gene Names
UniProt Entry Name
ACK1_HUMAN
NCBI Summary for TNK2
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for TNK2
Ack: a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described.
Protein type: EC 2.7.11.1; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Ack family
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: cytoplasmic vesicle membrane; clathrin-coated vesicle; dendrite; coated pit; extrinsic to internal side of plasma membrane; adherens junction; growth cone; cell soma; membrane; axon; cytoplasm; plasma membrane; nucleus; endosome
Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; WW domain binding; protein serine/threonine/tyrosine kinase activity; GTPase inhibitor activity; ATP binding; hormone receptor binding; epidermal growth factor receptor binding
Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; cell migration; cell surface receptor linked signal transduction; small GTPase mediated signal transduction; negative regulation of catalytic activity; innate immune response; endocytosis; cell differentiation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
Research Articles on TNK2
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Products associated with anti-TNK2 antibody
Pathways associated with anti-TNK2 antibody
Diseases associated with anti-TNK2 antibody
Organs/Tissues associated with anti-TNK2 antibody
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