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anti-ACK1 antibody :: Rabbit ACK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540940 anti-ACK1 antibody
Unit / Price
0.1 mg FITC  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACK1, Polyclonal Antibody

 Also Known As   

ACK1 Antibody FITC-Conjugated

 Product Synonym Names    Acetate kinase 1; TNK 2; Tyrosine kinase non receptor 2 antibody
 Product Gene Name   

anti-ACK1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ACK1 peptide (MBS542328) is used for blocking the activity of ACK1 antibody (MBS540940)
 Matching Pairs    Antibody: ACK1 (MBS540940)
Positive Control: ACK1 (MBS542502)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606994
 3D Structure    ModBase 3D Structure for Q07912
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    FITC-Conjugated
 Concentration    0.59-0.68 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 300-400 on ACK1 protein.
 Expression    During progressive stages in breast and prostate cancer
 Molecular Function    ATP binding; epidermal growth factor receptor binding; GTPase inhibitor activity; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine kinase activity
 Structure    Forms complexes with GRB2 and several receptor tyrosine kinases. Part of collagen stimulated complex.
 Subcellular Location    Cell membrane; Nucleus; Endosome; Cell junction; adherens junction; Cytoplasmic vessicle membrane; Peripheral membrane protein; Clathrin-coated vessicles; Clathin coated pit
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-ACK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACK1 antibody

   FITC-Conjugated Activated CDC42 kinase 1 Antibody
Non-receptor tyrosine-protein and serine/threonine-protein kinase implicated in cell sperading and migration, survival, growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors.
 Applications Tested/Suitable for anti-ACK1 antibody   

ELISA (EIA), IMM, Western Blot (WB)

 Application Notes for anti-ACK1 antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for ACK1. It may not necessarily be applicable to this product.
 NCBI GI #    8850244
 NCBI GeneID    10188
 NCBI Accession #    L13738.2 [Other Products]
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 UniProt Primary Accession #    Q07912 [Other Products]
 UniProt Secondary Accession #    Q6ZMQ0; Q8N6U7; Q96H59 [Other Products]
 UniProt Related Accession #    Q07912 [Other Products]
 Molecular Weight    119,349 Da
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 NCBI Official Full Name    Homo sapiens activated p21cdc42Hs kinase (ACK1) mRNA, complete cds
 NCBI Official Synonym Full Names    tyrosine kinase non receptor 2
 NCBI Official Symbol    TNK2 [Similar Products]
 NCBI Official Synonym Symbols   
ACK; ACK1; ACK-1; p21cdc42Hs
[Similar Products]
 NCBI Protein Information    activated CDC42 kinase 1
 UniProt Protein Name    Activated CDC42 kinase 1
 UniProt Synonym Protein Names   
Tyrosine kinase non-receptor protein 2
 Protein Family    Activator of C kinase protein
 UniProt Gene Name    TNK2 [Similar Products]
 UniProt Synonym Gene Names    ACK1; ACK-1 [Similar Products]
 UniProt Entry Name    ACK1_HUMAN
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 NCBI Summary for ACK1    This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACK1    Ack: a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described.

Protein type: Kinase, protein; Protein kinase, TK; EC 2.7.11.1; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Ack family

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: adherens junction; clathrin-coated vesicle; coated pit; cytoplasm; cytoplasmic vesicle membrane; endosome; extrinsic to internal side of plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: ATP binding; epidermal growth factor receptor binding; GTPase inhibitor activity; identical protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity; WW domain binding

Biological Process: cell differentiation; cell migration; cell surface receptor linked signal transduction; endocytosis; innate immune response; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cell proliferation; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on ACK1    1. that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic brake that stabilizes DAT at the plasma membrane.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACK1 antibodyPathways associated with anti-ACK1 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >49 publications with ACK1 and CDC42
 EGFR antibody  >15 publications with ACK1 and EGFR
 SRC antibody  >14 publications with ACK1 and SRC
 WWOX antibody  >4 publications with ACK1 and WWOX
 BCAR1 antibody  >3 publications with ACK1 and BCAR1
 GRB2 antibody  >3 publications with ACK1 and GRB2
 NCK1 antibody  >1 publications with ACK1 and NCK1
 SNX9 antibody  >1 publications with ACK1 and SNX9
 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
Diseases associated with anti-ACK1 antibodyOrgans/Tissues associated with anti-ACK1 antibody
 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >8 publications with ACK1 and Prostatic Diseases
 Genital Diseases, Male Antibodies  >8 publications with ACK1 and Genital Diseases, Male
 Neoplasm Metastasis Antibodies  >7 publications with ACK1 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >5 publications with ACK1 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >3 publications with ACK1 and Liver Diseases
 Kidney Diseases Antibodies  >3 publications with ACK1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >2 publications with ACK1 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with ACK1 and Carcinoma, Hepatocellular
 Hypertrophy Antibodies  >2 publications with ACK1 and Hypertrophy
 Hyperplasia Antibodies  >2 publications with ACK1 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >12 publications with ACK1 and Prostate
 Brain Antibodies  >8 publications with ACK1 and Brain
 Kidney Antibodies  >6 publications with ACK1 and Kidney
 Nerve Antibodies  >5 publications with ACK1 and Nerve
 Stomach Antibodies  >3 publications with ACK1 and Stomach
 Lung Antibodies  >3 publications with ACK1 and Lung
 Blood Antibodies  >3 publications with ACK1 and Blood
 Lymph Node Antibodies  >2 publications with ACK1 and Lymph Node
 Lymph Antibodies  >2 publications with ACK1 and Lymph
 Liver Antibodies  >2 publications with ACK1 and Liver
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