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anti-ACKR1 antibody :: Rabbit anti-Human, mouse ACKR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7005916
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACKR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

ACKR1 Antibody

 Product Synonym Names    Atypical chemokine receptor 1; Duffy antigen/chemokine receptor; Glycoprotein D; Plasmodium vivax receptor; ACKR1; DARC; FY; GPD
 Product Gene Name   

anti-ACKR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    110700
 3D Structure    ModBase 3D Structure for Q16570
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Atypical chemokine receptor 1 protrin (1-63AA)
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27815 / sc-27813
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ACKR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACKR1 antibody

   Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
 Applications Tested/Suitable for anti-ACKR1 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-ACKR1 antibody    Recommended dilution: WB:1:500-2000
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 Western Blot (WB) of anti-ACKR1 antibody    Western blot
All lanes: ACKR1 antibody at 2ug/ml
Lane 1:mouse kidney tissue
Lane 2mouse spleen tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 36kDa
Observed band size: 36kDa

anti-ACKR1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-ACKR1 antibody    Immunofluorescent analysis of HepG2 cells using MBS7005916 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ACKR1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ACKR1. It may not necessarily be applicable to this product.
 NCBI GI #    171846251
 NCBI GeneID    2532
 NCBI Accession #    NP_001116423.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001122951.2 [Other Products]
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 UniProt Primary Accession #    Q16570 [Other Products]
 UniProt Secondary Accession #    O75898; Q16300; Q8WWE3; Q9UJP0; Q9UKZ5; Q9UKZ6; Q9UQE1; A8YPG5 [Other Products]
 UniProt Related Accession #    Q16570 [Other Products]
 Molecular Weight    35,678 Da
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 NCBI Official Full Name    atypical chemokine receptor 1 isoform a
 NCBI Official Synonym Full Names    atypical chemokine receptor 1 (Duffy blood group)
 NCBI Official Symbol    ACKR1 [Similar Products]
 NCBI Official Synonym Symbols   
FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1
[Similar Products]
 NCBI Protein Information    atypical chemokine receptor 1
 UniProt Protein Name    Atypical chemokine receptor 1
 UniProt Synonym Protein Names   
Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD_antigen: CD234
 Protein Family    Atypical chemokine receptor
 UniProt Gene Name    ACKR1 [Similar Products]
 UniProt Synonym Gene Names    DARC; FY; GPD; GpFy [Similar Products]
 UniProt Entry Name    ACKR1_HUMAN
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 NCBI Summary for ACKR1    The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACKR1    DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, Duffy family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: early endosome; integral to membrane; plasma membrane; recycling endosome

Molecular Function: C-C chemokine binding; G-protein coupled receptor activity; receptor activity; transmembrane receptor activity

Biological Process: defense response; G-protein coupled receptor protein signaling pathway; inflammatory response; regulation of chemokine production

Disease: Blood Group, Duffy System; Malaria, Susceptibility To; White Blood Cell Count Quantitative Trait Locus 1
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 Research Articles on ACKR1    1. the odds for neutropenia in the ACKR1-null (FY-) individuals were 46-fold higher than for FY+ individuals (Crude odds ratio = 46, 95% confidence interval = 8.03-263, P < 0.001)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACKR1 antibodyPathways associated with anti-ACKR1 antibody
 Reference Product  PubMed Publications
 CCL2 antibody  >2 publications with ACKR1 and CCL2
 FYB antibody  >1 publications with ACKR1 and FYB
 CCL7 antibody  >1 publications with ACKR1 and CCL7
 CXCL1 antibody  >1 publications with ACKR1 and CXCL1
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-ACKR1 antibodyOrgans/Tissues associated with anti-ACKR1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with ACKR1 and Inflammation
 Atherosclerosis Antibodies  >1 publications with ACKR1 and Atherosclerosis
 Lung Diseases Antibodies  >1 publications with ACKR1 and Lung Diseases
 Heart Diseases Antibodies  >1 publications with ACKR1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with ACKR1 and Heart
 Vascular Antibodies  >1 publications with ACKR1 and Vascular
 Lung Antibodies  >1 publications with ACKR1 and Lung
 Brain Antibodies  >1 publications with ACKR1 and Brain
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