NP_001116423.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
atypical chemokine receptor 1 isoform a
NCBI Official Synonym Full Names
atypical chemokine receptor 1 (Duffy blood group)
NCBI Official Synonym Symbols
FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1 [Similar Products]
NCBI Protein Information
atypical chemokine receptor 1
UniProt Protein Name
Atypical chemokine receptor 1
UniProt Synonym Protein Names
Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD_antigen: CD234
UniProt Synonym Gene Names
UniProt Entry Name
ACKR1_HUMAN
NCBI Summary for ACKR1
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACKR1
DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, Duffy family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: early endosome; integral to membrane; plasma membrane; recycling endosome
Molecular Function: C-C chemokine binding; G-protein coupled receptor activity; receptor activity; transmembrane receptor activity
Biological Process: defense response; G-protein coupled receptor protein signaling pathway; inflammatory response; regulation of chemokine production
Disease: Blood Group, Duffy System; Malaria, Susceptibility To; White Blood Cell Count Quantitative Trait Locus 1
Research Articles on ACKR1
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Products associated with anti-ACKR1 antibody
Pathways associated with anti-ACKR1 antibody
Diseases associated with anti-ACKR1 antibody
Organs/Tissues associated with anti-ACKR1 antibody
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