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anti-ACKR4 antibody :: Rabbit ACKR4 / CCRL1 / CCR11 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243853
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACKR4 / CCRL1 / CCR11, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human ACKR4 / CCRL1 / CCR11

 Product Synonym Names    Anti-ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain) IHC-plus; ACKR4; C-C CKR-11; CC-CKR-11; CC chemokine receptor-like 1; CCR11; CCX CKR; C-C chemokine receptor type 11; CKR-11; CCRL1; VSHK1; CCR-11; CCX-CKR; PPR1; Human ACKR4; CCRL1; CCR11
 Product Gene Name   

anti-ACKR4 antibody

[Similar Products]
 Product Synonym Gene Name    CCRL1; CCR11 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606065
 3D Structure    ModBase 3D Structure for Q9NPB9
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bat, Gibbon, Dog, Gorilla, Horse, Human, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Monkey, Bovine, Hamster (at least 90% immunogen sequence identity)
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 Specificity    Human CCRL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CCR6 (63%).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 16 amino acid peptide from 1st cytoplasmic domain of human CCRL1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig (100%); Marmoset, Bovine.
 Immunogen Type    Synthetic peptide
 Immunogen    ACKR4 / CCRL1 / CCR11 antibody was raised against synthetic 16 amino acid peptide from 1st cytoplasmic domain of human CCRL1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig (100%); Marmoset, Bovine, Hamster, Opossum (94%); Turkey, Chicken, Xenopus (81%).
 Antigen Modification    Cytoplasmic Domain
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-ACKR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACKR4 antibody

   CCRL1, a Chemokine Receptor, responds to monocyte chemoattractant proteins (MCP) (Schweickart et al., 2000).
 Product Categories/Family for anti-ACKR4 antibody    Family: GPCR
Subfamily: Chemokine
 Applications Tested/Suitable for anti-ACKR4 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-ACKR4 antibody    IHC-P (24 ug/ml)
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 Immunohistochemistry (IHC) of anti-ACKR4 antibody    Anti-ACKR4 / CCRL1 / CCR11 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ACKR4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ACKR4 antibody    Anti-ACKR4 / CCRL1 / CCR11 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ACKR4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ACKR4 antibody    Anti-CCRL1 antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ACKR4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ACKR4. It may not necessarily be applicable to this product.
 NCBI GI #    7706769
 NCBI GeneID    51554
 NCBI Accession #    NP_057641.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016557.3 [Other Products]
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 UniProt Primary Accession #    Q9NPB9 [Other Products]
 UniProt Secondary Accession #    B2R9U7 [Other Products]
 UniProt Related Accession #    Q9NPB9 [Other Products]
 Molecular Weight    39,914 Da
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 NCBI Official Full Name    atypical chemokine receptor 4
 NCBI Official Synonym Full Names    atypical chemokine receptor 4
 NCBI Official Symbol    ACKR4 [Similar Products]
 NCBI Official Synonym Symbols   
PPR1; CCBP2; CCR10; CCR11; CCRL1; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11
[Similar Products]
 NCBI Protein Information    atypical chemokine receptor 4; C-C CKR-11; CC chemokine receptor-like 1; C-C chemokine receptor type 11; chemocentryx chemokine receptor; chemokine (C-C motif) receptor-like 1; chemokine, cc motif, receptor-like protein 1; orphan seven-transmembrane receptor, chemokine related
 UniProt Protein Name    Atypical chemokine receptor 4
 UniProt Synonym Protein Names   
C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKR
 Protein Family    Atypical chemokine receptor
 UniProt Gene Name    ACKR4 [Similar Products]
 UniProt Synonym Gene Names    CCBP2; CCR11; CCRL1; VSHK1; C-C CKR-11; CC-CKR-11; CCR-11; CCRL1 [Similar Products]
 UniProt Entry Name    ACKR4_HUMAN
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 NCBI Summary for ACKR4    The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
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 UniProt Comments for ACKR4    CCRL1: Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q22

Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane

Molecular Function: protein binding; chemokine receptor activity; chemokine binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; immune response; chemotaxis
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 Research Articles on ACKR4    1. we found that CCX-CKR expression in vitro could modulate cellular migration and invasion abilities, potentially via the regulation of other chemotactic factors/receptors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACKR4 antibodyPathways associated with anti-ACKR4 antibody
 Reference Product  PubMed Publications
 CCL21 antibody  >1 publications with ACKR4 and CCL21
 CCL19 antibody  >1 publications with ACKR4 and CCL19
 CCL25 antibody  >1 publications with ACKR4 and CCL25
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
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