P53396.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,099 Da
NCBI Official Full Name
ATP-citrate synthase
NCBI Official Synonym Full Names
ATP citrate lyase
NCBI Protein Information
ATP-citrate synthase
UniProt Protein Name
ATP-citrate synthase
UniProt Synonym Protein Names
ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzyme
UniProt Synonym Gene Names
UniProt Entry Name
ACLY_HUMAN
NCBI Summary for ACLY
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for ACLY
ACLY: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.3.3.8; Transferase; Lyase; Carbohydrate Metabolism - citrate (TCA) cycle
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleoplasm; plasma membrane
Molecular Function: ATP binding; ATP citrate synthase activity; cofactor binding; metal ion binding; protein binding
Biological Process: acetyl-CoA biosynthetic process; cellular lipid metabolic process; cholesterol biosynthetic process; citrate metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; lipid biosynthetic process; oxaloacetate metabolic process; positive regulation of cellular metabolic process; triacylglycerol biosynthetic process
Research Articles on ACLY
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Products associated with anti-ACLY antibody
Pathways associated with anti-ACLY antibody
Diseases associated with anti-ACLY antibody
Organs/Tissues associated with anti-ACLY antibody
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