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anti-ACS5 antibody :: Goat ACS5 / ACSL5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242212
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACS5 / ACSL5, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat Polyclonal to Human ACS5 / ACSL5

 Product Synonym Names    Anti-ACS5 / ACSL5 Antibody (C-Terminus) IHC-plus; ACSL5; ACS2; ACS5; FACL5; Fatty acid coenzyme A ligase 5; Phosphatidylinositol 4-kinase; LACS 5; Human ACS5; ACSL5
 Product Gene Name   

anti-ACS5 antibody

[Similar Products]
 Product Synonym Gene Name    ACSL5 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605677
 3D Structure    ModBase 3D Structure for Q9ULC5
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Gibbon, Gorilla, Human, Monkey
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 Specificity    Human ACSL5. This antibody is expected to recognise isoform a (NP_057318.2) and isoform b (NP_976313.1 and NP_976314.1).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-RTQIDSLYEHIQD from the C-terminus of human ACSL5 (NP_057318.2; NP_976313.1; NP_976314.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda (85%).
 Immunogen Type    Synthetic peptide
 Immunogen    ACS5 / ACSL5 antibody was raised against synthetic peptide C-RTQIDSLYEHIQD from the C-terminus of human ACSL5 (NP_057318.2; NP_976313.1; NP_976314.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda (85%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-ACS5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ACS5 antibody    Family: Non-Protein Kinase
 Applications Tested/Suitable for anti-ACS5 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ACS5 antibody    ELISA (1:16000), IHC-P (2.5 ug/ml), WB (1 - 3 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-ACS5 antibody    Anti-ACSL5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACS5 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ACS5 antibody    Antibody (1 ug/ml) staining of human spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ACS5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACS5. It may not necessarily be applicable to this product.
 NCBI GI #    42794756
 NCBI GeneID    51703
 NCBI Accession #    NP_057318.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_016234.3 [Other Products]
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 UniProt Primary Accession #    Q9ULC5 [Other Products]
 UniProt Secondary Accession #    Q6UX44; Q9UIU4; A6GV77; D3DRB3 [Other Products]
 UniProt Related Accession #    Q9ULC5 [Other Products]
 Molecular Weight    73,278 Da
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 NCBI Official Full Name    long-chain-fatty-acid--CoA ligase 5 isoform a
 NCBI Official Synonym Full Names    acyl-CoA synthetase long-chain family member 5
 NCBI Official Symbol    ACSL5 [Similar Products]
 NCBI Official Synonym Symbols   
ACS2; ACS5; FACL5
[Similar Products]
 NCBI Protein Information    long-chain-fatty-acid--CoA ligase 5; LACS 5; fatty acid coenzyme A ligase 5; long-chain acyl-CoA synthetase 5; FACL5 for fatty acid coenzyme A ligase 5; long-chain fatty acid coenzyme A ligase 5; fatty-acid-Coenzyme A ligase, long-chain 5
 UniProt Protein Name    Long-chain-fatty-acid--CoA ligase 5
 UniProt Synonym Protein Names   
Long-chain acyl-CoA synthetase 5; LACS 5
 Protein Family    1-aminocyclopropane-1-carboxylate synthase
 UniProt Gene Name    ACSL5 [Similar Products]
 UniProt Synonym Gene Names    ACS5; FACL5; LACS 5 [Similar Products]
 UniProt Entry Name    ACSL5_HUMAN
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 NCBI Summary for ACS5    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACS5    ACSL5: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. It was suggested that it may also stimulate fatty acid oxidation. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 6.2.1.3; Lipid Metabolism - fatty acid; Mitochondrial; Ligase

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; nucleolus; integral to membrane; nucleus

Molecular Function: ATP binding; long-chain-fatty-acid-CoA ligase activity

Biological Process: triacylglycerol biosynthetic process; long-chain fatty acid metabolic process; cellular lipid metabolic process
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 Research Articles on ACS5    1. Down-regulation of ACSL5 is associated with colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACS5 antibodyPathways associated with anti-ACS5 antibody
 Reference Product  PubMed Publications
 CPT1B antibody  >2 publications with ACS5 and CPT1B
 ELOVL6 antibody  >1 publications with ACS5 and ELOVL6
 ACADL antibody  >1 publications with ACS5 and ACADL
 ACADM antibody  >1 publications with ACS5 and ACADM
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
Diseases associated with anti-ACS5 antibodyOrgans/Tissues associated with anti-ACS5 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >10 publications with ACS5 and Fatty Liver
 Liver Diseases Antibodies  >5 publications with ACS5 and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with ACS5 and Liver Neoplasms
 Necrosis Antibodies  >3 publications with ACS5 and Necrosis
 Weight Loss Antibodies  >2 publications with ACS5 and Weight Loss
 Carcinoma, Hepatocellular Antibodies  >2 publications with ACS5 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >2 publications with ACS5 and Inflammation
 Weight Gain Antibodies  >1 publications with ACS5 and Weight Gain
 Hyperplasia Antibodies  >1 publications with ACS5 and Hyperplasia
 Hepatomegaly Antibodies  >1 publications with ACS5 and Hepatomegaly
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with ACS5 and Liver
 Intestine Antibodies  >9 publications with ACS5 and Intestine
 Blood Antibodies  >6 publications with ACS5 and Blood
 Muscle Antibodies  >4 publications with ACS5 and Muscle
 Connective Tissue Antibodies  >3 publications with ACS5 and Connective Tissue
 Lung Antibodies  >3 publications with ACS5 and Lung
 Brain Antibodies  >3 publications with ACS5 and Brain
 Pancreas Antibodies  >2 publications with ACS5 and Pancreas
 Vascular Antibodies  >2 publications with ACS5 and Vascular
 Heart Antibodies  >2 publications with ACS5 and Heart
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