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anti-ACSL4 antibody :: Rabbit anti-Human ACSL4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004469
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACSL4, Polyclonal Antibody

★Popular Item★
 Also Known As   

ACSL4 Antibody

 Product Synonym Names    Long-chain-fatty-acid--CoA ligase 4; Long-chain acyl-CoA synthetase 4; LACS 4; ACSL4; ACS4; FACL4; LACS4
 Product Gene Name   

anti-ACSL4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300157
 3D Structure    ModBase 3D Structure for O60488
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Long-chain-fatty-acid--CoA ligase 4 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47995 / sc-47997 / sc-47996
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ACSL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACSL4 antibody

   Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
 Applications Tested/Suitable for anti-ACSL4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ACSL4 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-ACSL4 antibody    Western blot
All lanes: ACSL4 antibody at 2ug/ml
Lane 1:HepG2 whole cell lysate
Lane 2:Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 80,75 kDa
Observed band size: 79 kDa

anti-ACSL4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ACSL4 antibody    Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7004469 at dilution 1:100
anti-ACSL4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ACSL4 antibody    Immunohistochemistry of paraffin-embedded human breast cancer tissue using MBS7004469 at dilution 1:100
anti-ACSL4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ACSL4. It may not necessarily be applicable to this product.
 NCBI GI #    4758332
 NCBI GeneID    2182
 NCBI Accession #    NP_004449.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004458.2 [Other Products]
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 UniProt Primary Accession #    O60488 [Other Products]
 UniProt Secondary Accession #    O60848; O60849; Q5JWV8; D3DUY2 [Other Products]
 UniProt Related Accession #    O60488 [Other Products]
 Molecular Weight    74,436 Da
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 NCBI Official Full Name    long-chain-fatty-acid--CoA ligase 4 isoform 1
 NCBI Official Synonym Full Names    acyl-CoA synthetase long-chain family member 4
 NCBI Official Symbol    ACSL4 [Similar Products]
 NCBI Official Synonym Symbols   
ACS4; FACL4; LACS4; MRX63; MRX68
[Similar Products]
 NCBI Protein Information    long-chain-fatty-acid--CoA ligase 4
 UniProt Protein Name    Long-chain-fatty-acid--CoA ligase 4
 UniProt Synonym Protein Names   
Long-chain acyl-CoA synthetase 4; LACS 4
 UniProt Gene Name    ACSL4 [Similar Products]
 UniProt Synonym Gene Names    ACS4; FACL4; LACS4; LACS 4 [Similar Products]
 UniProt Entry Name    ACSL4_HUMAN
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 NCBI Summary for ACSL4    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
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 UniProt Comments for ACSL4    ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligase; EC 6.2.1.3; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: Xq22.3-q23

Cellular Component: cell soma; cytoplasm; endoplasmic reticulum membrane; integral to membrane; lipid particle; membrane; mitochondrial outer membrane; peroxisomal membrane

Molecular Function: arachidonate-CoA ligase activity; ATP binding; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity

Biological Process: cellular lipid metabolic process; embryonic process involved in female pregnancy; fatty acid transport; lipid biosynthetic process; lipid metabolic process; long-chain fatty acid metabolic process; negative regulation of prostaglandin secretion; positive regulation of cell growth; response to nutrient; triacylglycerol biosynthetic process

Disease: Mental Retardation, X-linked 63
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 Research Articles on ACSL4    1. In vitro analysis showed that a recombinant COX-2 enzyme more effectively metabolized 5(S)-HETE to 5-11-diHETE compared to COX-1 enzyme.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACSL4 antibodyPathways associated with anti-ACSL4 antibody
 Reference Product  PubMed Publications
 HTATIP2 antibody  >2 publications with ACSL4 and HTATIP2
 COL4A5 antibody  >2 publications with ACSL4 and COL4A5
 LPL antibody  >1 publications with ACSL4 and LPL
 AMMECR1 antibody  >1 publications with ACSL4 and AMMECR1
 CPT1A antibody  >1 publications with ACSL4 and CPT1A
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
Diseases associated with anti-ACSL4 antibodyOrgans/Tissues associated with anti-ACSL4 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >15 publications with ACSL4 and Fatty Liver
 Nervous System Diseases Antibodies  >8 publications with ACSL4 and Nervous System Diseases
 Liver Diseases Antibodies  >4 publications with ACSL4 and Liver Diseases
 Inflammation Antibodies  >4 publications with ACSL4 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >4 publications with ACSL4 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >3 publications with ACSL4 and Disease Models, Animal
 Abnormalities, Multiple Antibodies  >3 publications with ACSL4 and Abnormalities, Multiple
 Fibrosis Antibodies  >1 publications with ACSL4 and Fibrosis
 Kidney Diseases Antibodies  >1 publications with ACSL4 and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with ACSL4 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >15 publications with ACSL4 and Liver
 Muscle Antibodies  >12 publications with ACSL4 and Muscle
 Blood Antibodies  >10 publications with ACSL4 and Blood
 Brain Antibodies  >10 publications with ACSL4 and Brain
 Adipose Tissue Antibodies  >6 publications with ACSL4 and Adipose Tissue
 Heart Antibodies  >4 publications with ACSL4 and Heart
 Testis Antibodies  >3 publications with ACSL4 and Testis
 Connective Tissue Antibodies  >3 publications with ACSL4 and Connective Tissue
 Vascular Antibodies  >2 publications with ACSL4 and Vascular
 Prostate Antibodies  >2 publications with ACSL4 and Prostate
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