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anti-ACTC1 antibody :: Rabbit ACTC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9603805
Western Blot (WB)
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTC1, Polyclonal Antibody

★Popular Item★
 Also Known As   

ACTC1 Antibody

 Product Synonym Names    ACTC; ACTC_HUMAN; ACTC1; Actin alpha cardiac muscle 1; Actin; alpha cardiac muscle 1; Alpha-cardiac actin; ASD5; CMD1R; CMH11; LVNC4
 Product Gene Name   

anti-ACTC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P68032
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    ACTC1 antibody detects endogenous levels of total ACTC1
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide
 Subcellular Location    Cytoplasm > Cytoskeleton.
 Conjugation    Unconjugated
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 Other Notes    Small volumes of anti-ACTC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACTC1 antibody

   Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit Structure: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
Post-translational Modifications: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).
Similarity: Belongs to the actin family.
 Applications Tested/Suitable for anti-ACTC1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ACTC1 antibody    WB: 1:500-1:2000
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 Western Blot (WB) of anti-ACTC1 antibody    Western blot analysis of ACTC1 expression in NIH3T3 whole cell lysate ;, The lane on the left is treated with the antigen-specific peptide.
anti-ACTC1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACTC1. It may not necessarily be applicable to this product.
 NCBI GI #    4885049
 NCBI GeneID    70
 NCBI Accession #    NP_005150.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005159.4 [Other Products]
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 UniProt Primary Accession #    P68032 [Other Products]
 UniProt Secondary Accession #    P04270 [Other Products]
 UniProt Related Accession #    P68032 [Other Products]
 Molecular Weight    Observed: 42 kDa
Predicted: 43 kDa
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 NCBI Official Full Name    actin, alpha cardiac muscle 1
 NCBI Official Synonym Full Names    actin, alpha, cardiac muscle 1
 NCBI Official Symbol    ACTC1 [Similar Products]
 NCBI Official Synonym Symbols   
ACTC; ASD5; CMD1R; CMH11; LVNC4
[Similar Products]
 NCBI Protein Information    actin, alpha cardiac muscle 1
 UniProt Protein Name    Actin, alpha cardiac muscle 1
 UniProt Synonym Protein Names   
Alpha-cardiac actin
 Protein Family    Actin
 UniProt Gene Name    ACTC1 [Similar Products]
 UniProt Synonym Gene Names    ACTC [Similar Products]
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 NCBI Summary for ACTC1    Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACTC1    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
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 Research Articles on ACTC1    1. These findings suggest that the familial ostium secundum atrial septal defect (ASDII)may be a result of an ACTC1 3'UTR gain-of-function mutation caused by the introduction of a new miR-139-5p target site. Our results provide the first evidence of a pathogenic mutation in the ACTC1 3'UTR that may be associated with familial isolated ASDII.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACTC1 antibodyPathways associated with anti-ACTC1 antibody
 Reference Product  PubMed Publications
 MYH7 antibody  >9 publications with ACTC1 and MYH7
 MYH6 antibody  >4 publications with ACTC1 and MYH6
 ACTA1 antibody  >1 publications with ACTC1 and ACTA1
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with anti-ACTC1 antibodyOrgans/Tissues associated with anti-ACTC1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >18 publications with ACTC1 and Cardiovascular Diseases
 Cardiomyopathy, Dilated Antibodies  >7 publications with ACTC1 and Cardiomyopathy, Dilated
 Cardiomyopathy, Familial Hypertrophic, 1 Antibodies  >3 publications with ACTC1 and Cardiomyopathy, Familial Hypertrophic, 1
 Neoplasms Antibodies  >2 publications with ACTC1 and Neoplasms
 Hypertrophy Antibodies  >2 publications with ACTC1 and Hypertrophy
 Cardiomyopathy, Familial Hypertrophic, 11 Antibodies  >2 publications with ACTC1 and Cardiomyopathy, Familial Hypertrophic, 11
 Disease Models, Animal Antibodies  >2 publications with ACTC1 and Disease Models, Animal
 Lung Diseases Antibodies  >1 publications with ACTC1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >1 publications with ACTC1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with ACTC1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >23 publications with ACTC1 and Muscle
 Heart Antibodies  >17 publications with ACTC1 and Heart
 Vascular Antibodies  >3 publications with ACTC1 and Vascular
 Lung Antibodies  >2 publications with ACTC1 and Lung
 Embryonic Tissue Antibodies  >2 publications with ACTC1 and Embryonic Tissue
 Bone Antibodies  >1 publications with ACTC1 and Bone
 Prostate Antibodies  >1 publications with ACTC1 and Prostate
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