NP_004292.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
actin-like protein 6A isoform 1
NCBI Official Synonym Full Names
actin like 6A
NCBI Official Synonym Symbols
Arp4; ACTL6; BAF53A; INO80K; ARPN-BETA [Similar Products]
NCBI Protein Information
actin-like protein 6A
UniProt Protein Name
Actin-like protein 6A
UniProt Synonym Protein Names
53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K
UniProt Synonym Gene Names
UniProt Entry Name
ACL6A_HUMAN
NCBI Summary for ACTL6A
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTL6A
BAF53A: an actin-related protein involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of the helicase SMARCA4 and for association of the SMARCA4 containing remodelling complex BAF with chromatin/nuclear matrix. A component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of specific genes. Two alternatively spliced human isoforms have been described.
Chromosomal Location of Human Ortholog: 3q26.33
Cellular Component: nucleoplasm; SWI/SNF complex; NuA4 histone acetyltransferase complex; protein complex; nuclear chromatin; plasma membrane; nucleus
Molecular Function: protein binding; nucleosomal DNA binding; transcription coactivator activity; chromatin binding
Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; spinal cord development; regulation of growth; ATP-dependent chromatin remodeling; signal transduction; DNA repair; DNA recombination
Product References and Citations for anti-ACTL6A antibody
Zhao K.,et al.Cell 95:625-636(1998).
Harata M.,et al.Biosci. Biotechnol. Biochem. 63:917-923(1999).
Harata M.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Research Articles on ACTL6A
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Products associated with anti-ACTL6A antibody
Pathways associated with anti-ACTL6A antibody
Diseases associated with anti-ACTL6A antibody
Organs/Tissues associated with anti-ACTL6A antibody
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