Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ACTL6A rightarrow Polyclonal ACTL6A  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Stress-induced protein SAM22 Recombinant Protein
 • Birinapant Biochemical
 • Free Fatty Acid (FFA) ELISA Kit
 • Anti GM2 (ganglioside) Antibody IgM (GM2 Ab IgM) ELISA Kit
 • Lipopolysaccharides (LPS) ELISA Kit
 • DnaJ homolog subfamily B member 9 (Dnajb9) Recombinant Protein
 • Vascular Endothelial Growth Factor (VEGF) ELISA Kit
 • CD8 - HLADR Antibody
 • ADCY6 Positive Control
 • b-Galactosidase Enzyme
 • Glucose Transporter GLUT4 Positive Control
 • EZH1 Antibody
 • Tar DNA Binding Protein 43 (TDP43) ELISA Kit
 • WNT7A Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ACTL6A antibody :: Rabbit ACTL6A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2525570
Western Blot (WB)
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTL6A, Polyclonal Antibody

 Also Known As   

ACTL6A Antibody

 Product Synonym Names    Arp4; ACTL6; BAF53A; INO80K; ARPN-BETA
 Product Gene Name   

anti-ACTL6A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    604958
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen affinity purification
 Concentration    1mg/mL (lot specific)
Section Bar
 Immunogen    Recombinant protein of human ACTL6A
 Observed Molecular Weight: 47kDa   
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47808 / sc-47805
Section Bar
 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-ACTL6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-ACTL6A antibody

   This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
 Applications Tested/Suitable for anti-ACTL6A antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), CHIP

Section Bar
 Western Blot (WB) of anti-ACTL6A antibody    Western blot analysis of extracts of various cell lines, using ACTL6A antibody.
anti-ACTL6A antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ACTL6A. It may not necessarily be applicable to this product.
 NCBI GI #    30089999
 NCBI GeneID    86
 NCBI Accession #    NP_829888.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_178042.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q8TAE5; Q9BVS8; Q9H0W6; B3KMN1; D3DNR9 [Other Products]
 UniProt Related Accession #    O96019 [Other Products]
 Molecular Weight    43,236 Da
Table BarTOPTable Bar
 NCBI Official Full Name    actin-like protein 6A isoform 2
 NCBI Official Synonym Full Names    actin-like 6A
 NCBI Official Symbol    ACTL6A [Similar Products]
 NCBI Official Synonym Symbols   
Arp4; ACTL6; BAF53A; INO80K; ARPN-BETA
[Similar Products]
 NCBI Protein Information    actin-like protein 6A; 53 kDa BRG1-associated factor A; BAF complex 53 kDa subunit; BAF53; BRG1-associated factor 53A; INO80 complex subunit K; actin-related protein 4; actin-related protein Baf53a; arpNbeta; hArpN beta
 UniProt Protein Name    Actin-like protein 6A
 UniProt Synonym Protein Names   
53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K
 Protein Family    Actin-like protein
 UniProt Gene Name    ACTL6A [Similar Products]
 UniProt Synonym Gene Names    BAF53; BAF53A; INO80K; BAF53A [Similar Products]
 UniProt Entry Name    ACL6A_HUMAN
Section Bar
 NCBI Summary for ACTL6A    This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for ACTL6A    BAF53A: an actin-related protein involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of the helicase SMARCA4 and for association of the SMARCA4 containing remodelling complex BAF with chromatin/nuclear matrix. A component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of specific genes. Two alternatively spliced human isoforms have been described.

Chromosomal Location of Human Ortholog: 3q26.33

Cellular Component: nucleoplasm; SWI/SNF complex; NuA4 histone acetyltransferase complex; protein complex; nuclear chromatin; plasma membrane; nucleus

Molecular Function: protein binding; nucleosomal DNA binding; transcription coactivator activity; chromatin binding

Biological Process: regulation of transcription from RNA polymerase II promoter; chromatin remodeling; nervous system development; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; ATP-dependent chromatin remodeling; DNA repair; signal transduction; DNA recombination
Table BarTOPTable Bar
 Research Articles on ACTL6A    1. These results indicate that failure to downregulate the BAF53a subunit may contribute to the pathogenesis of rhabdomyosarcoma, and suggest that BAF53a may represent a novel therapeutic target for this tumor.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-ACTL6A antibodyPathways associated with anti-ACTL6A antibody
 Reference Product  PubMed Publications
 SMARCA4 antibody  >7 publications with ACTL6A and SMARCA4
 SMARCA2 antibody  >3 publications with ACTL6A and SMARCA2
 RUVBL1 antibody  >1 publications with ACTL6A and RUVBL1
 RUVBL2 antibody  >1 publications with ACTL6A and RUVBL2
 FLII antibody  >1 publications with ACTL6A and FLII
 Products by Pathway  Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Gastric Cancer Network 1 Pathway antibodies  Gastric Cancer Network 1 Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
Diseases associated with anti-ACTL6A antibodyOrgans/Tissues associated with anti-ACTL6A antibody
 Disease Name  Pubmed Publications
 Memory Disorders Antibodies  >2 publications with ACTL6A and Memory Disorders
 Disease Models, Animal Antibodies  >2 publications with ACTL6A and Disease Models, Animal
 Anemia Antibodies  >1 publications with ACTL6A and Anemia
 Neurobehavioral Manifestations Antibodies  >1 publications with ACTL6A and Neurobehavioral Manifestations
 Neoplasms, Experimental Antibodies  >1 publications with ACTL6A and Neoplasms, Experimental
 Uterine Cervical Neoplasms Antibodies  >1 publications with ACTL6A and Uterine Cervical Neoplasms
 Kidney Diseases Antibodies  >1 publications with ACTL6A and Kidney Diseases
 Learning Disorders Antibodies  >1 publications with ACTL6A and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with ACTL6A and Brain
 Muscle Antibodies  >2 publications with ACTL6A and Muscle
 Kidney Antibodies  >2 publications with ACTL6A and Kidney
 Blood Antibodies  >2 publications with ACTL6A and Blood
 Nerve Antibodies  >1 publications with ACTL6A and Nerve
 Bone Marrow Antibodies  >1 publications with ACTL6A and Bone Marrow
 Heart Antibodies  >1 publications with ACTL6A and Heart
 Liver Antibodies  >1 publications with ACTL6A and Liver
 Embryonic Tissue Antibodies  >1 publications with ACTL6A and Embryonic Tissue
 Bone Antibodies  >1 publications with ACTL6A and Bone
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions