NP_005727.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,614 Da
NCBI Official Full Name
alpha-centractin
NCBI Official Synonym Full Names
ARP1 actin-related protein 1 homolog A, centractin alpha
NCBI Protein Information
alpha-centractin
UniProt Protein Name
Alpha-centractin
UniProt Synonym Protein Names
ARP1; Actin-RPV; Centrosome-associated actin homolog
UniProt Synonym Gene Names
NCBI Summary for ACTR1A
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTR1A
ACTR1A: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. Belongs to the actin family. ARP1 subfamily.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: centrosome; cytoplasm; cytosol; microtubule associated complex; microtubule cytoskeleton
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; G2/M transition of mitotic cell cycle; vesicle-mediated transport
Research Articles on ACTR1A
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Products associated with anti-ACTR1A antibody
Pathways associated with anti-ACTR1A antibody
Diseases associated with anti-ACTR1A antibody
Organs/Tissues associated with anti-ACTR1A antibody
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