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anti-ACTR1B antibody :: Goat ACTR1B / PC3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242204
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTR1B / PC3, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human ACTR1B / PC3

 Product Synonym Names    Anti-ACTR1B / PC3 Antibody (C-Terminus) IHC-plus; ACTR1B; Actin-related protein 1B; Beta-centractin; Centractin beta; PC3; ARP1B; CTRN2; Human ACTR1B; PC3
 Product Gene Name   

anti-ACTR1B antibody

[Similar Products]
 Product Synonym Gene Name    PC3 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605144
 3D Structure    ModBase 3D Structure for P42025
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Bovine, Dog, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Bat, Hamster, Chicken, Xenopus (at least 90% immunogen sequence identity)
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 Specificity    Human ACTR1B. This epitope was selected to minimise the chance of cross-reactivity with ACTR1A (YEEDGARSIHRKT).
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-YEEDGSRAIHRKT from the C-terminus of human ACTR1B (NP_005726.1). Percent identity by BLAST analysis: Human, Monkey, Marmoset, Mouse, Rat, Panda, Dog, Bovine, Horse, Rabbit, Pig (100%).
 Immunogen Type    Synthetic peptide
 Immunogen    ACTR1B / PC3 antibody was raised against synthetic peptide C-YEEDGSRAIHRKT from the C-terminus of human ACTR1B (NP_005726.1). Percent identity by BLAST analysis: Human, Monkey, Marmoset, Mouse, Rat, Panda, Dog, Bovine, Horse, Rabbit, Pig (100%); Hamster, Bat, Opossum, Turkey, Chicken, Platypus, Xenopus (92%); Gorilla, Gibbon, Elephant, Salmon, Stickleback, Zebrafish, Mosquito (85%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-ACTR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ACTR1B antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ACTR1B antibody    ELISA (1:128000), IHC-P (3.75 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-ACTR1B antibody    Anti-ACTR1B antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
anti-ACTR1B antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ACTR1B antibody    Antibody staining (1 ug/ml) of human heart lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
anti-ACTR1B antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACTR1B. It may not necessarily be applicable to this product.
 NCBI GI #    11342680
 NCBI GeneID    10120
 NCBI Accession #    NP_005726.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005735.3 [Other Products]
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 UniProt Primary Accession #    P42025 [Other Products]
 UniProt Secondary Accession #    Q53SK5; Q9BRB7; D3DVH2 [Other Products]
 UniProt Related Accession #    P42025 [Other Products]
 Molecular Weight    42,293 Da
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 NCBI Official Full Name    beta-centractin
 NCBI Official Synonym Full Names    ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
 NCBI Official Symbol    ACTR1B [Similar Products]
 NCBI Official Synonym Symbols   
PC3; ARP1B; CTRN2
[Similar Products]
 NCBI Protein Information    beta-centractin; centractin beta; actin-related protein 1B
 UniProt Protein Name    Beta-centractin
 UniProt Synonym Protein Names   
Actin-related protein 1B; ARP1B
 Protein Family    Beta-centractin
 UniProt Gene Name    ACTR1B [Similar Products]
 UniProt Synonym Gene Names    CTRN2; ARP1B [Similar Products]
 UniProt Entry Name    ACTY_HUMAN
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 NCBI Summary for ACTR1B    This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]
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 UniProt Comments for ACTR1B    ACTR1B: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. Belongs to the actin family. ARP1 subfamily.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: centrosome; dynactin complex; membrane; cytoplasm; cytosol

Molecular Function: protein binding; ATP binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II
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 Research Articles on ACTR1B    1. Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ACTR1B antibodyDiseases associated with anti-ACTR1B antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >1 publications with ACTR1B and Infertility, Male
Organs/Tissues associated with anti-ACTR1B antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >1 publications with ACTR1B and Embryonic Tissue
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